2-[[3-(2-Amino-1,2-dioxoethyl)-2-methyl-1-benzyl-1,6,7,8-tetrahydrocyclopent[g]indol-4-yl]oxy]acetic Acid

Base Information

Chemical Name:2-[[3-(2-Amino-1,2-dioxoethyl)-2-methyl-1-benzyl-1,6,7,8-tetrahydrocyclopent[g]indol-4-yl]oxy]acetic Acid
CAS No.:438623-59-7
Molecular Formula:C₂₃H₂₂N₂O₅
Molecular Weight:406.438
Hs Code.:

Synonyms:2-[[3-(2-Amino-1,2-dioxoethyl)-2-methyl-1-benzyl-1,6,7,8-tetrahydrocyclopent[g]indol-4-yl]oxy]acetic Acid

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Chemical Property of 2-[[3-(2-Amino-1,2-dioxoethyl)-2-methyl-1-benzyl-1,6,7,8-tetrahydrocyclopent[g]indol-4-yl]oxy]acetic Acid

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Technology Process of 2-[[3-(2-Amino-1,2-dioxoethyl)-2-methyl-1-benzyl-1,6,7,8-tetrahydrocyclopent[g]indol-4-yl]oxy]acetic Acid

There total 12 articles about 2-[[3-(2-Amino-1,2-dioxoethyl)-2-methyl-1-benzyl-1,6,7,8-tetrahydrocyclopent[g]indol-4-yl]oxy]acetic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 438623-58-6
2-[[3-(2-Amino-1,2-dioxoethyl)-2-methyl-1-benzyl-1,6,7,8-tetrahydrocyclopent[g]indol-4-yl]oxy]acetic acid methyl ester

: 438623-59-7
2-[[3-(2-Amino-1,2-dioxoethyl)-2-methyl-1-benzyl-1,6,7,8-tetrahydrocyclopent[g]indol-4-yl]oxy]acetic Acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 19h;
DOI:10.1021/jm0401309

Reference yield:

: 5111-69-3
5-methoxyindane

: 438623-59-7
2-[[3-(2-Amino-1,2-dioxoethyl)-2-methyl-1-benzyl-1,6,7,8-tetrahydrocyclopent[g]indol-4-yl]oxy]acetic Acid

Guidance literature:: Multi-step reaction with 12 steps

1.1: POCl₃ / 0.5 h / 0 °C

1.2: 73 percent / 4 h / 80 °C

2.1: 53 percent / NaOEt / diethyl ether; ethanol / 3 h / -10 - 20 °C

3.1: 52 percent / toluene / 6 h / Heating

4.1: NaH / dimethylformamide / 0.25 h

4.2: dimethylformamide / 48 h / 20 °C

5.1: 37.5 g / aq. NaOH / methanol; tetrahydrofuran; dimethylformamide / 50 °C

6.1: 100 percent / LiAlH₄ / tetrahydrofuran / 18 h / 20 °C

7.1: 26 percent / H₂ / Pd/C / tetrahydrofuran; ethanol; CHCl₃ / 18 h / 2327.17 - 2585.74 Torr

8.1: BBr₃ / CHCl₃ / 2.5 h / 20 °C

9.1: 0.43 g / Cs₂CO₃ / dimethylformamide / 18 h / 20 °C

10.1: CH₂Cl₂ / 1 h / 0 °C

11.1: 0.28 g / NH₃ / CH₂Cl₂; dioxane / 0.5 h

12.1: 71 percent / aq. LiOH / methanol; tetrahydrofuran / 19 h / 20 °C

With lithium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; ammonia; hydrogen; sodium ethanolate; boron tribromide; sodium hydride; caesium carbonate; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene; 1.2: Vilsmeier reaction;
DOI:10.1021/jm0401309

Reference yield:

: 73615-83-5
2,3-dihydro-6-methoxy-1H-indene-5-carboxaldehyde

: 438623-59-7
2-[[3-(2-Amino-1,2-dioxoethyl)-2-methyl-1-benzyl-1,6,7,8-tetrahydrocyclopent[g]indol-4-yl]oxy]acetic Acid

Guidance literature:: Multi-step reaction with 11 steps

1.1: 53 percent / NaOEt / diethyl ether; ethanol / 3 h / -10 - 20 °C

2.1: 52 percent / toluene / 6 h / Heating

3.1: NaH / dimethylformamide / 0.25 h

3.2: dimethylformamide / 48 h / 20 °C

4.1: 37.5 g / aq. NaOH / methanol; tetrahydrofuran; dimethylformamide / 50 °C

5.1: 100 percent / LiAlH₄ / tetrahydrofuran / 18 h / 20 °C

6.1: 26 percent / H₂ / Pd/C / tetrahydrofuran; ethanol; CHCl₃ / 18 h / 2327.17 - 2585.74 Torr

7.1: BBr₃ / CHCl₃ / 2.5 h / 20 °C

8.1: 0.43 g / Cs₂CO₃ / dimethylformamide / 18 h / 20 °C

9.1: CH₂Cl₂ / 1 h / 0 °C

10.1: 0.28 g / NH₃ / CH₂Cl₂; dioxane / 0.5 h

11.1: 71 percent / aq. LiOH / methanol; tetrahydrofuran / 19 h / 20 °C

With lithium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; ammonia; hydrogen; sodium ethanolate; boron tribromide; sodium hydride; caesium carbonate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm0401309