(6R,7R)-7-{(S)-3-[2-[(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohexylidene]-eth-(E)-ylidene]-1-methyl-cyclohexyl}-2,6-dimethyl-oct-3-yn-2-ol

Base Information

Chemical Name:(6R,7R)-7-{(S)-3-[2-[(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohexylidene]-eth-(E)-ylidene]-1-methyl-cyclohexyl}-2,6-dimethyl-oct-3-yn-2-ol
CAS No.:181116-77-8
Molecular Formula:C₃₇H₆₈O₃Si₂
Molecular Weight:617.116
Hs Code.:

Synonyms:(6R,7R)-7-{(S)-3-[2-[(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohexylidene]-eth-(E)-ylidene]-1-methyl-cyclohexyl}-2,6-dimethyl-oct-3-yn-2-ol

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Chemical Property of (6R,7R)-7-{(S)-3-[2-[(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohexylidene]-eth-(E)-ylidene]-1-methyl-cyclohexyl}-2,6-dimethyl-oct-3-yn-2-ol

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Technology Process of (6R,7R)-7-{(S)-3-[2-[(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohexylidene]-eth-(E)-ylidene]-1-methyl-cyclohexyl}-2,6-dimethyl-oct-3-yn-2-ol

There total 11 articles about (6R,7R)-7-{(S)-3-[2-[(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohexylidene]-eth-(E)-ylidene]-1-methyl-cyclohexyl}-2,6-dimethyl-oct-3-yn-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: C₄₁H₇₆O₄Si₂

: 181116-77-8
(6R,7R)-7-{(S)-3-[2-[(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohexylidene]-eth-(E)-ylidene]-1-methyl-cyclohexyl}-2,6-dimethyl-oct-3-yn-2-ol

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane; Ambient temperature;
DOI:10.1016/0960-894X(96)00301-0

Reference yield:

: 248916-04-3
(S)-3-((1R,2S)-3-Benzyloxy-1,2-dimethyl-propyl)-3-methyl-cyclohexanol

: 181116-77-8
(6R,7R)-7-{(S)-3-[2-[(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohexylidene]-eth-(E)-ylidene]-1-methyl-cyclohexyl}-2,6-dimethyl-oct-3-yn-2-ol

Guidance literature:: Multi-step reaction with 8 steps

1: 95 percent / imidazole, DMAP / dimethylformamide

2: 95 percent / cyclohexene / Pd(OH)2/C / ethanol / Heating

3: pyridine

4: 68 percent / NaH / dimethylsulfoxide

5: TBAF / tetrahydrofuran / 30 °C

6: 85 percent / PDC

7: 89 percent / n-BuLi / tetrahydrofuran / -78 °C

8: 95 percent / PPTS / CH₂Cl₂ / Ambient temperature

With 1H-imidazole; dmap; dipyridinium dichromate; n-butyllithium; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; sodium hydride; cyclohexene; palladium dihydroxide; In tetrahydrofuran; pyridine; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/0960-894X(96)00301-0

Reference yield:

: 248916-02-1
Toluene-4-sulfonic acid (2R,3S)-4-benzyloxy-3-methyl-2-((S)-1-methyl-cyclohex-2-enyl)-butyl ester

: 181116-77-8
(6R,7R)-7-{(S)-3-[2-[(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohexylidene]-eth-(E)-ylidene]-1-methyl-cyclohexyl}-2,6-dimethyl-oct-3-yn-2-ol

Guidance literature:: Multi-step reaction with 10 steps

1: LAH / tetrahydrofuran

2: 95 percent / 9-BBN, H₂O₂

3: 95 percent / imidazole, DMAP / dimethylformamide

4: 95 percent / cyclohexene / Pd(OH)2/C / ethanol / Heating

5: pyridine

6: 68 percent / NaH / dimethylsulfoxide

7: TBAF / tetrahydrofuran / 30 °C

8: 85 percent / PDC

9: 89 percent / n-BuLi / tetrahydrofuran / -78 °C

10: 95 percent / PPTS / CH₂Cl₂ / Ambient temperature

With 1H-imidazole; dmap; lithium aluminium tetrahydride; dipyridinium dichromate; 9-borabicyclo[3.3.1]nonane dimer; n-butyllithium; tetrabutyl ammonium fluoride; dihydrogen peroxide; pyridinium p-toluenesulfonate; sodium hydride; cyclohexene; palladium dihydroxide; In tetrahydrofuran; pyridine; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/0960-894X(96)00301-0