morpholine-4-carboxylic acid {(S)-[1-(1-cyano-cyclopropyl)-1H-[1,2,3]triazol-4-yl]-cyclohexyl-methyl}-amide

Base Information

Chemical Name:morpholine-4-carboxylic acid {(S)-[1-(1-cyano-cyclopropyl)-1H-[1,2,3]triazol-4-yl]-cyclohexyl-methyl}-amide
CAS No.:1333425-33-4
Molecular Formula:C₁₈H₂₆N₆O₂
Molecular Weight:358.443
Hs Code.:

Synonyms:morpholine-4-carboxylic acid {(S)-[1-(1-cyano-cyclopropyl)-1H-[1,2,3]triazol-4-yl]-cyclohexyl-methyl}-amide

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Chemical Property of morpholine-4-carboxylic acid {(S)-[1-(1-cyano-cyclopropyl)-1H-[1,2,3]triazol-4-yl]-cyclohexyl-methyl}-amide

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Technology Process of morpholine-4-carboxylic acid {(S)-[1-(1-cyano-cyclopropyl)-1H-[1,2,3]triazol-4-yl]-cyclohexyl-methyl}-amide

There total 11 articles about morpholine-4-carboxylic acid {(S)-[1-(1-cyano-cyclopropyl)-1H-[1,2,3]triazol-4-yl]-cyclohexyl-methyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1333428-27-5
C₁₈H₂₈N₆O₃

: 1333425-33-4
morpholine-4-carboxylic acid {(S)-[1-(1-cyano-cyclopropyl)-1H-[1,2,3]triazol-4-yl]-cyclohexyl-methyl}-amide

Guidance literature:: With 1,3,5-trichloro-2,4,6-triazine; In N,N-dimethyl-formamide; for 14h;

Reference yield:

: 1333426-91-7
(S)-N-((S)-1-cyclohexyl-3-(trimethylsilyl)prop-2-yn-1-yl)-tert-butylsulfinamide

: 1333425-33-4
morpholine-4-carboxylic acid {(S)-[1-(1-cyano-cyclopropyl)-1H-[1,2,3]triazol-4-yl]-cyclohexyl-methyl}-amide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide; water / methanol

2: sodium L-ascorbate; copper(II) sulfate / ethanol; water / 16 h

3: hydrogenchloride / 1,4-dioxane; methanol / 1 h

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h

5: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 14 h

With hydrogenchloride; 1,3,5-trichloro-2,4,6-triazine; water; copper(II) sulfate; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: (S)-N-(cyclohexylmethylene)-2-methylpropane-2-sulfinamide

: 1333425-33-4
morpholine-4-carboxylic acid {(S)-[1-(1-cyano-cyclopropyl)-1H-[1,2,3]triazol-4-yl]-cyclohexyl-methyl}-amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / toluene; hexane / 0.25 h / -78 °C

1.2: 2 h / -78 °C

2.1: sodium hydroxide; water / methanol

3.1: sodium L-ascorbate; copper(II) sulfate / ethanol; water / 16 h

4.1: hydrogenchloride / 1,4-dioxane; methanol / 1 h

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h

6.1: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 14 h

With hydrogenchloride; n-butyllithium; 1,3,5-trichloro-2,4,6-triazine; water; copper(II) sulfate; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene;