4-{[3-(4-Chlorophenyl)-4-cyclopropyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}-3-methoxybenzenecarboxylic acid

Base Information

Chemical Name:4-{[3-(4-Chlorophenyl)-4-cyclopropyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}-3-methoxybenzenecarboxylic acid
CAS No.:1228650-27-8
Molecular Formula:C₂₀H₁₈ClN₃O₄
Molecular Weight:399.834
Hs Code.:

Synonyms:4-{[3-(4-Chlorophenyl)-4-cyclopropyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}-3-methoxybenzenecarboxylic acid

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Chemical Property of 4-{[3-(4-Chlorophenyl)-4-cyclopropyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}-3-methoxybenzenecarboxylic acid

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Technology Process of 4-{[3-(4-Chlorophenyl)-4-cyclopropyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}-3-methoxybenzenecarboxylic acid

There total 3 articles about 4-{[3-(4-Chlorophenyl)-4-cyclopropyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}-3-methoxybenzenecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1228650-26-7
Methyl 4-{[3-(4-chlorophenyl)-4-cyclopropyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}-3-methoxybenzenecarboxylate

: 1228650-27-8
4-{[3-(4-Chlorophenyl)-4-cyclopropyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}-3-methoxybenzenecarboxylic acid

Guidance literature:: Methyl 4-{[3-(4-chlorophenyl)-4-cyclopropyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}-3-methoxybenzenecarboxylate; With sodium hydroxide; In tetrahydrofuran; methanol; at 80 ℃; for 1h;

With hydrogenchloride; In water;

Reference yield:

: 70264-94-7
methyl 4-(bromomethyl)-3-methoxybenzoate

: 1228650-27-8
4-{[3-(4-Chlorophenyl)-4-cyclopropyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}-3-methoxybenzenecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / acetone / 2 h / 60 °C

2: sodium hydroxide / tetrahydrofuran; methanol / 1 h / 80 °C

With caesium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; acetone;

Reference yield:

: 959137-49-6
5-(4-chlorophenyl)-4-cyclopropyl-2,4-dihydro-3H-1,2,4-triazol-3-one

: 1228650-27-8
4-{[3-(4-Chlorophenyl)-4-cyclopropyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}-3-methoxybenzenecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / acetone / 2 h / 60 °C

2: sodium hydroxide / tetrahydrofuran; methanol / 1 h / 80 °C

With caesium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; acetone;