4,5-Dibenzyl-5-hydroxy Albuterol Acid Methyl Ester

Base Information

• Chemical Name: 4,5-Dibenzyl-5-hydroxy Albuterol Acid Methyl Ester
• CAS No.: 182676-93-3
• Molecular Formula: C₂₈H₃₃NO₅
• Molecular Weight: 463.574
• Mol file: 182676-93-3.mol

Synonyms:2,3-Bis-benzyloxy-5-(2-tert-butylamino-1-hydroxy-ethyl)-benzoic acid methyl ester

Chemical Property of 4,5-Dibenzyl-5-hydroxy Albuterol Acid Methyl Ester

Chemical Property:

• Storage Temp.: Amber Vial, Refrigerator, Under inert atmosphere
• Solubility.: Dichloromethane, Dimethylsulfoxide, Tetrahydrofuran

Purity/Quality:

99% ^*data from raw suppliers

4,5-Dibenzyl-5-hydroxy Albuterol Acid Methyl Ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,5-Dibenzyl-5-hydroxy Albuterol Acid Methyl Ester

There total 6 articles about 4,5-Dibenzyl-5-hydroxy Albuterol Acid Methyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-Dihydroxybenzoic acid (303-38-8) → 2,3-Bis-benzyloxy-5-(2-tert-butylamino-1-hydroxy-ethyl)-benzoic acid methyl ester (182676-93-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 71 percent / Br₂, HOAc / 20 h / Ambient temperature

2: 84 percent / H₂SO₄ / 16 h / Heating

3: 65 percent / NaH / dimethylformamide / 18 h / 0 deg C -> room temperature

4: 87 percent / Pd(PPh₃)2Cl₂ / toluene / 96 °C

5: m-chloroperoxybenzoic acid, aq. NaHCO₃ / CH₂Cl₂ / 18 h / 0 deg C -> room temperature

6: propan-2-ol / Heating

With bis-triphenylphosphine-palladium(II) chloride; sulfuric acid; bromine; sodium hydride; sodium hydrogencarbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

DOI:10.1016/0960-894X(96)00413-1

Reference yield:

2,3-dihydroxy-5-bromobenzoic acid (72517-15-8) → 2,3-Bis-benzyloxy-5-(2-tert-butylamino-1-hydroxy-ethyl)-benzoic acid methyl ester (182676-93-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 84 percent / H₂SO₄ / 16 h / Heating

2: 65 percent / NaH / dimethylformamide / 18 h / 0 deg C -> room temperature

3: 87 percent / Pd(PPh₃)2Cl₂ / toluene / 96 °C

4: m-chloroperoxybenzoic acid, aq. NaHCO₃ / CH₂Cl₂ / 18 h / 0 deg C -> room temperature

5: propan-2-ol / Heating

With bis-triphenylphosphine-palladium(II) chloride; sulfuric acid; sodium hydride; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

DOI:10.1016/0960-894X(96)00413-1

Reference yield:

methyl 5-bromo-2,3-dihydroxybenzoate (105603-49-4) → 2,3-Bis-benzyloxy-5-(2-tert-butylamino-1-hydroxy-ethyl)-benzoic acid methyl ester (182676-93-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 65 percent / NaH / dimethylformamide / 18 h / 0 deg C -> room temperature

2: 87 percent / Pd(PPh₃)2Cl₂ / toluene / 96 °C

3: m-chloroperoxybenzoic acid, aq. NaHCO₃ / CH₂Cl₂ / 18 h / 0 deg C -> room temperature

4: propan-2-ol / Heating

With bis-triphenylphosphine-palladium(II) chloride; sodium hydride; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

DOI:10.1016/0960-894X(96)00413-1

upstream raw materials:

tert-butylamine

2,3-Dihydroxybenzoic acid

2,3-dihydroxy-5-bromobenzoic acid

methyl 5-bromo-2,3-dihydroxybenzoate

Downstream raw materials:

1-(3,4-Bis-benzyloxy-5-hydroxymethyl-phenyl)-2-tert-butylamino-ethanol