Chemical Property of 2-Bromo-4'-hydroxyacetophenone
Chemical Property:
- Appearance/Colour:clear colorless to light yellow liquid
- Melting Point:123-126°C
- Refractive Index:1.591
- Boiling Point:338.7 °C at 760 mmHg
- PKA:7.69±0.15(Predicted)
- Flash Point:158.6 °C
- PSA：37.30000
- Density:1.622 g/cm3
- LogP:1.96980
- Storage Temp.:-70°C
- Sensitive.:Lachrymatory
- Solubility.:Chloroform (Slightly), Methanol (Slightly)
- XLogP3:2.4
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:2
- Exact Mass:213.96294
- Heavy Atom Count:11
- Complexity:139
- Purity/Quality:
-
99% *data from raw suppliers
2-Bromo-4''-hydroxyacetophenone *data from reagent suppliers
Safty Information:
- Pictogram(s):
C
- Hazard Codes:C,Xn
- Statements:
22-36
- Safety Statements:
26
- MSDS Files:
-
SDS file from LookChem
Useful:
- Chemical Classes:Other Uses -> Biocides/Disinfectants
- Canonical SMILES:C1=CC(=CC=C1C(=O)CBr)O
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Description
PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with a Ki value of 43 μM and PTP1B with a Ki value of 42 μM. SHP-1 and PTP1B both have known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research.
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Uses
A covalent inhibitor of protein tyrosine phosphatases (PTPs)
