methyl 2-(3-((4-bromo-2-fluorophenyl)amino)-2-oxoquinoxalin-1(2H)-yl)acetate

Base Information

Chemical Name:methyl 2-(3-((4-bromo-2-fluorophenyl)amino)-2-oxoquinoxalin-1(2H)-yl)acetate
CAS No.:1374748-45-4
Molecular Formula:C₁₇H₁₃BrFN₃O₃
Molecular Weight:406.211
Hs Code.:

Synonyms:methyl 2-(3-((4-bromo-2-fluorophenyl)amino)-2-oxoquinoxalin-1(2H)-yl)acetate

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Chemical Property of methyl 2-(3-((4-bromo-2-fluorophenyl)amino)-2-oxoquinoxalin-1(2H)-yl)acetate

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Technology Process of methyl 2-(3-((4-bromo-2-fluorophenyl)amino)-2-oxoquinoxalin-1(2H)-yl)acetate

There total 4 articles about methyl 2-(3-((4-bromo-2-fluorophenyl)amino)-2-oxoquinoxalin-1(2H)-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 35676-70-1
3-chloro-quinoxaline-2(1H)-one

: 367-24-8
4-bromo-2-fluoroaniline

: 96-32-2
bromoacetic acid methyl ester

: 1374748-45-4
methyl 2-(3-((4-bromo-2-fluorophenyl)amino)-2-oxoquinoxalin-1(2H)-yl)acetate

Guidance literature:: 3-chloro-quinoxaline-2(1H)-one; 4-bromo-2-fluoroaniline; In acetonitrile; at 85 ℃; for 24h;

bromoacetic acid methyl ester; With potassium carbonate; In acetonitrile; at 55 ℃; for 0.5h;
DOI:10.1002/cmdc.201200054

Reference yield:

: 2213-63-0
2,3-dichloroquinoxaline

: 1374748-45-4
methyl 2-(3-((4-bromo-2-fluorophenyl)amino)-2-oxoquinoxalin-1(2H)-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; lithium hydroxide / tetrahydrofuran / 24 h / 65 °C

2.1: acetonitrile / 24 h / 85 °C

2.2: 0.5 h / 55 °C

With water; lithium hydroxide; In tetrahydrofuran; acetonitrile;
DOI:10.1002/cmdc.201200054

Reference yield:

: 15804-19-0,6287-20-3
quinoxaline-2,3-dione

: 1374748-45-4
methyl 2-(3-((4-bromo-2-fluorophenyl)amino)-2-oxoquinoxalin-1(2H)-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 6 h / 45 °C

2.1: water; lithium hydroxide / tetrahydrofuran / 24 h / 65 °C

3.1: acetonitrile / 24 h / 85 °C

3.2: 0.5 h / 55 °C

With thionyl chloride; water; lithium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/cmdc.201200054