2-[2-({5-chloro-2-[(2-methylpropyl)oxy]phenyl}methyl)-1,3-oxazol-4-yl]-1H-benzimidazole hydrochloride

Base Information

Chemical Name:2-[2-({5-chloro-2-[(2-methylpropyl)oxy]phenyl}methyl)-1,3-oxazol-4-yl]-1H-benzimidazole hydrochloride
CAS No.:913653-23-3
Molecular Formula:C₂₁H₂₀ClN₃O₂*ClH
Molecular Weight:418.323
Hs Code.:

Synonyms:2-[2-({5-chloro-2-[(2-methylpropyl)oxy]phenyl}methyl)-1,3-oxazol-4-yl]-1H-benzimidazole hydrochloride

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Chemical Property of 2-[2-({5-chloro-2-[(2-methylpropyl)oxy]phenyl}methyl)-1,3-oxazol-4-yl]-1H-benzimidazole hydrochloride

Chemical Property:

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Technology Process of 2-[2-({5-chloro-2-[(2-methylpropyl)oxy]phenyl}methyl)-1,3-oxazol-4-yl]-1H-benzimidazole hydrochloride

There total 9 articles about 2-[2-({5-chloro-2-[(2-methylpropyl)oxy]phenyl}methyl)-1,3-oxazol-4-yl]-1H-benzimidazole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 913685-82-2
C₂₁H₂₀ClN₃O₂

: 913653-23-3
2-[2-({5-chloro-2-[(2-methylpropyl)oxy]phenyl}methyl)-1,3-oxazol-4-yl]-1H-benzimidazole hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; dichloromethane;

Reference yield:

: 913651-30-6
2-((5-chloro-2-[(2-methylpropyl)oxy]phenyl)methyl)-1,3-oxazole-4-carboxylic acid

: 913653-23-3
2-[2-({5-chloro-2-[(2-methylpropyl)oxy]phenyl}methyl)-1,3-oxazol-4-yl]-1H-benzimidazole hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

2: trichlorophosphate / 1 h / 75 °C

3: sodium hydride / 16 h / 20 °C

4: methanol / 4 h / Heating / reflux

5: hydrogenchloride / diethyl ether; dichloromethane

With hydrogenchloride; oxalyl dichloride; sodium hydride; N,N-dimethyl-formamide; trichlorophosphate; In methanol; diethyl ether; dichloromethane;

Reference yield:

: 2-({5-chloro-2-[(2-methylpropyl)oxy]phenyl}methyl)-1,3-oxazole-4-carboxamide

: 913653-23-3
2-[2-({5-chloro-2-[(2-methylpropyl)oxy]phenyl}methyl)-1,3-oxazol-4-yl]-1H-benzimidazole hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 1 h / 75 °C

2: sodium hydride / 16 h / 20 °C

3: methanol / 4 h / Heating / reflux

4: hydrogenchloride / diethyl ether; dichloromethane

With hydrogenchloride; sodium hydride; trichlorophosphate; In methanol; diethyl ether; dichloromethane;