(4S,1'S)-3-(2',2'-dimethyl-1'-phenyl-1'-propylamino)-4-phenylmethyl-2-oxazolidinone

Base Information

Chemical Name:(4S,1'S)-3-(2',2'-dimethyl-1'-phenyl-1'-propylamino)-4-phenylmethyl-2-oxazolidinone
CAS No.:299216-29-8
Molecular Formula:C₂₁H₂₆N₂O₂
Molecular Weight:338.45
Hs Code.:

Synonyms:(4S,1'S)-3-(2',2'-dimethyl-1'-phenyl-1'-propylamino)-4-phenylmethyl-2-oxazolidinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S,1'S)-3-(2',2'-dimethyl-1'-phenyl-1'-propylamino)-4-phenylmethyl-2-oxazolidinone

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Technology Process of (4S,1'S)-3-(2',2'-dimethyl-1'-phenyl-1'-propylamino)-4-phenylmethyl-2-oxazolidinone

There total 8 articles about (4S,1'S)-3-(2',2'-dimethyl-1'-phenyl-1'-propylamino)-4-phenylmethyl-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 558-17-8
tert-Butyl iodide

: 299216-18-5
(S)-3-(benzylidene)amino-4-phenylmethyl-2-oxazolidinone

: 299216-29-8
(4S,1'S)-3-(2',2'-dimethyl-1'-phenyl-1'-propylamino)-4-phenylmethyl-2-oxazolidinone

: (4S,1'R)-3-(2',2'-dimethyl-1'-phenyl-1'-propylamino)-4-phenylmethyl-2-oxazolidinone

Guidance literature:: With oxygen; tri-n-butyl-tin hydride; zinc(II) chloride; In diethyl ether; dichloromethane; at -78 - 20 ℃;
DOI:10.1021/ja002173u

Reference yield:

: 90719-32-7
(S)-4-Benzyl-2-oxazolidinone

: 299216-29-8
(4S,1'S)-3-(2',2'-dimethyl-1'-phenyl-1'-propylamino)-4-phenylmethyl-2-oxazolidinone

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / n-BuLi; O-(mesitylenesulfonyl)hydroxylamine / tetrahydrofuran; hexane / -78 - 20 °C

2: p-toluenesulfonic acid / toluene / 1 h / Heating

3: ZnCl₂; Et₃B; O₂ / Bu₃SnH / CH₂Cl₂; diethyl ether / 48 h / 20 °C

With n-butyllithium; triethyl borane; oxygen; mesitylenesulfonylhydroxylamine; toluene-4-sulfonic acid; zinc(II) chloride; tri-n-butyl-tin hydride; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; toluene;
DOI:10.1021/jo050756m

Reference yield:

: 299216-13-0
(S)-3-amino-4-benzyl-1,3-oxazolan-2-one

: 299216-29-8
(4S,1'S)-3-(2',2'-dimethyl-1'-phenyl-1'-propylamino)-4-phenylmethyl-2-oxazolidinone

Guidance literature:: Multi-step reaction with 2 steps

1: p-toluenesulfonic acid / toluene / 1 h / Heating

2: ZnCl₂; Et₃B; O₂ / Bu₃SnH / CH₂Cl₂; diethyl ether / 48 h / 20 °C

With triethyl borane; oxygen; toluene-4-sulfonic acid; zinc(II) chloride; tri-n-butyl-tin hydride; In diethyl ether; dichloromethane; toluene;
DOI:10.1021/jo050756m