4-N-benzoyl-5'-O-[di(2-cyanoethyloxy)phosphoryl]-2'-deoxycytidylyl-{3'-O^P-(2-cyanoethyl)->5'}-6-N-benzoyladenosine

Base Information

• Chemical Name: 4-N-benzoyl-5'-O-[di(2-cyanoethyloxy)phosphoryl]-2'-deoxycytidylyl-{3'-O^P-(2-cyanoethyl)->5'}-6-N-benzoyladenosine
• CAS No.: 357624-05-6
• Molecular Formula: C₄₂H₄₃N₁₁O₁₅P₂
• Molecular Weight: 1003.82
• Mol file: 357624-05-6.mol

Synonyms:4-N-benzoyl-5'-O-[di(2-cyanoethyloxy)phosphoryl]-2'-deoxycytidylyl-{3'-O^P-(2-cyanoethyl)->5'}-6-N-benzoyladenosine

Chemical Property of 4-N-benzoyl-5'-O-[di(2-cyanoethyloxy)phosphoryl]-2'-deoxycytidylyl-{3'-O^P-(2-cyanoethyl)->5'}-6-N-benzoyladenosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-N-benzoyl-5'-O-[di(2-cyanoethyloxy)phosphoryl]-2'-deoxycytidylyl-{3'-O^P-(2-cyanoethyl)->5'}-6-N-benzoyladenosine

There total 5 articles about 4-N-benzoyl-5'-O-[di(2-cyanoethyloxy)phosphoryl]-2'-deoxycytidylyl-{3'-O^P-(2-cyanoethyl)->5'}-6-N-benzoyladenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-N-benzoyl-5'-O-[di(2-cyanoethyloxy)phosphoryl]-2'-deoxycytidylyl-{3'-OP-(2-cyanoethyl)->5'}-6-N-benzoyl-2',3'-O-isopropylideneadenosine (357624-04-5) → 4-N-benzoyl-5'-O-[di(2-cyanoethyloxy)phosphoryl]-2'-deoxycytidylyl-{3'-OP-(2-cyanoethyl)->5'}-6-N-benzoyladenosine (357624-05-6)

Guidance literature:

With hydrogenchloride; at 20 ℃; for 3.5h;

DOI:10.1081/NCN-100002081

Reference yield:

bis(2-cyanoethyl) diisopropylamidophosphite (102690-88-0) → 4-N-benzoyl-5'-O-[di(2-cyanoethyloxy)phosphoryl]-2'-deoxycytidylyl-{3'-OP-(2-cyanoethyl)->5'}-6-N-benzoyladenosine (357624-05-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1H-tetrazole / CH₂Cl₂ / 3.5 h / 20 °C

2: 548 mg / I₂; pyridine; H₂O / CH₂Cl₂; tetrahydrofuran / 0.17 h / 20 °C

3: 90 percent / 1M HCl / 3.5 h / 20 °C

With pyridine; 1H-tetrazole; hydrogenchloride; water; iodine; In tetrahydrofuran; dichloromethane;

DOI:10.1081/NCN-100002081

Reference yield:

4-N-benzoyl-2'-deoxycytidylyl-{3'-OP-(2-cyanoethyl)->5'}-6-N-benzoyl-2',3'-O-isopropylideneadenosine (357624-02-3) → 4-N-benzoyl-5'-O-[di(2-cyanoethyloxy)phosphoryl]-2'-deoxycytidylyl-{3'-OP-(2-cyanoethyl)->5'}-6-N-benzoyladenosine (357624-05-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1H-tetrazole / CH₂Cl₂ / 3.5 h / 20 °C

2: 548 mg / I₂; pyridine; H₂O / CH₂Cl₂; tetrahydrofuran / 0.17 h / 20 °C

3: 90 percent / 1M HCl / 3.5 h / 20 °C

With pyridine; 1H-tetrazole; hydrogenchloride; water; iodine; In tetrahydrofuran; dichloromethane;

DOI:10.1081/NCN-100002081

upstream raw materials:

4-N-benzoyl-5'-O-[di(2-cyanoethyloxy)phosphoryl]-2'-deoxycytidylyl-{3'-O^P-(2-cyanoethyl)->5'}-6-N-benzoyl-2',3'-O-isopropylideneadenosine

bis(2-cyanoethyl) diisopropylamidophosphite

4-N-benzoyl-2'-deoxycytidylyl-{3'-O^P-(2-cyanoethyl)->5'}-6-N-benzoyl-2',3'-O-isopropylideneadenosine

Downstream raw materials:

5'-O-phosphoryl-2'-deoxycytidylyl-(3'->5')adenosine