N-methyl-N-(2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenoxy)phenyl)methanesulfonamide

Base Information

Chemical Name:N-methyl-N-(2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenoxy)phenyl)methanesulfonamide
CAS No.:1256333-87-5
Molecular Formula:C₂₀H₂₆N₂O₄S
Molecular Weight:390.503
Hs Code.:

Synonyms:N-methyl-N-(2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenoxy)phenyl)methanesulfonamide

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Chemical Property of N-methyl-N-(2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenoxy)phenyl)methanesulfonamide

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Technology Process of N-methyl-N-(2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenoxy)phenyl)methanesulfonamide

There total 7 articles about N-methyl-N-(2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenoxy)phenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1301223-61-9
N-(2-(4-hydroxyphenoxy)phenyl)-N-methylmethanesulfonamide

: 7250-67-1
1-(2-chloroethyl)pyrrolidine hydrochloride

: 1256333-87-5
N-methyl-N-(2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenoxy)phenyl)methanesulfonamide

Guidance literature:: N-(2-(4-hydroxyphenoxy)phenyl)-N-methylmethanesulfonamide; With potassium hydroxide; In N,N-dimethyl-formamide; at 80 - 90 ℃; for 0.166667h;

1-(2-chloroethyl)pyrrolidine hydrochloride; In N,N-dimethyl-formamide; at 100 ℃; for 0.5h;
DOI:10.1021/jm200063s

Reference yield:

: 105901-39-1
2-(4-Methoxyphenoxy)benzenamine

: 1256333-87-5
N-methyl-N-(2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenoxy)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 1 h / 70 - 90 °C / Reflux

2.1: potassium carbonate / acetone / 3 h / Reflux

3.1: boron tribromide / dichloromethane / 3 h / 0 - 20 °C

4.1: potassium hydroxide / N,N-dimethyl-formamide / 0.17 h / 80 - 90 °C

4.2: 0.5 h / 100 °C

With pyridine; boron tribromide; potassium carbonate; potassium hydroxide; In dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm200063s

Reference yield:

: 721448-65-3
N-(2-(4-methoxyphenoxy)phenyl)methanesulfonamide

: 1256333-87-5
N-methyl-N-(2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenoxy)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / 3 h / Reflux

2.1: boron tribromide / dichloromethane / 3 h / 0 - 20 °C

3.1: potassium hydroxide / N,N-dimethyl-formamide / 0.17 h / 80 - 90 °C

3.2: 0.5 h / 100 °C

With boron tribromide; potassium carbonate; potassium hydroxide; In dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm200063s