2,3-Difluoro-6-nitroanisole

Base Information

• Chemical Name: 2,3-Difluoro-6-nitroanisole
• CAS No.: 66684-65-9
• Molecular Formula: C7H5F2NO3
• Molecular Weight: 189.1163
• Mol file: 66684-65-9.mol

Synonyms:1,2,3-Trifluoro-4-methoxy-5-nitrobenzene;

Chemical Property of 2,3-Difluoro-6-nitroanisole

Chemical Property:

• Vapor Pressure: 0.0215mmHg at 25°C
• Refractive Index: 1.502
• Boiling Point: 259 °C at 760 mmHg
• Flash Point: 110.4 °C
• PSA: 55.05000
• Density: 1.414 g/cm³
• LogP: 2.54390
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

2,3-Difluoro-6-nitroanisole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-Difluoro-6-nitroanisole

There total 1 articles about 2,3-Difluoro-6-nitroanisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methoxy-2,3,4-trifluorobenzene (203245-16-3) → 1,2,3-trifluoro-4-methoxy-5-nitrobenzene (66684-65-9)

Guidance literature:

With nitric acid; acetic acid; at 60 ℃; for 3h;

Reference yield:

1,2,3-trifluoro-4-methoxy-5-nitrobenzene (66684-65-9) → tert-butyl 4-(4-amino-2,6-difluoro-3-methoxyphenyl)piperazine-1-carboxylate (1386951-37-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 3 h / 80 °C

2: hydrogen / Raney Nickel / methanol / 14 h

With hydrogen; potassium carbonate; Raney Nickel; In methanol; acetonitrile;

upstream raw materials:

1-methoxy-2,3,4-trifluorobenzene

Downstream raw materials:

tert-butyl 4-(4-amino-2,6-difluoro-3-methoxyphenyl)piperazine-1-carboxylate

Refernces