Technology Process of 2-(3,4-dimethoxyphenyl)-5-(4-methoxyphenyl)thiophene
There total 7 articles about 2-(3,4-dimethoxyphenyl)-5-(4-methoxyphenyl)thiophene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0); caesium carbonate;
In
1,2-dimethoxyethane; ethanol; water;
at 150 ℃;
for 0.25h;
under 11251.1 Torr;
Microwave irradiation;
DOI:10.1021/jm901195w
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 24 h / Reflux; Inert atmosphere
2.1: potassium hydroxide / toluene / 24 h / 65 °C
3.1: N-butylamine; copper(l) chloride; hydroxylamine hydrochloride / water / 0 °C
3.2: 5 h / 0 °C
4.1: palladium diacetate; triphenylphosphine; copper(l) iodide; tetra(n-butyl)ammonium hydroxide / toluene; water / 0.17 h / 95 °C / Inert atmosphere
5.1: sodium monohydrogen sulfide x-hydrate / toluene; water / 12 h / 60 - 80 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium monohydrogen sulfide x-hydrate; hydroxylamine hydrochloride; tetra(n-butyl)ammonium hydroxide; palladium diacetate; N-butylamine; triethylamine; triphenylphosphine; copper(l) chloride; potassium hydroxide;
In
water; toluene;
DOI:10.1002/ejoc.201801242
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium hydroxide / toluene / 24 h / 65 °C
2.1: N-butylamine; copper(l) chloride; hydroxylamine hydrochloride / water / 0 °C
2.2: 5 h / 0 °C
3.1: palladium diacetate; triphenylphosphine; copper(l) iodide; tetra(n-butyl)ammonium hydroxide / toluene; water / 0.17 h / 95 °C / Inert atmosphere
4.1: sodium monohydrogen sulfide x-hydrate / toluene; water / 12 h / 60 - 80 °C / Inert atmosphere
With
copper(l) iodide; sodium monohydrogen sulfide x-hydrate; hydroxylamine hydrochloride; tetra(n-butyl)ammonium hydroxide; palladium diacetate; N-butylamine; triphenylphosphine; copper(l) chloride; potassium hydroxide;
In
water; toluene;
DOI:10.1002/ejoc.201801242