1-((2R,4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-{2-[(2S,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-4-methoxy-tetrahydro-furan-2-ylmethylsulfanyl]-ethyl}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:1-((2R,4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-{2-[(2S,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-4-methoxy-tetrahydro-furan-2-ylmethylsulfanyl]-ethyl}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
CAS No.:174088-80-3
Molecular Formula:C₄₃H₄₈N₄O₁₁S
Molecular Weight:828.94
Hs Code.:

1-((2R,4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-{2-[(2S,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-4-methoxy-tetrahydro-furan-2-ylmethylsulfanyl]-ethyl}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

Synonyms:1-((2R,4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-{2-[(2S,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-4-methoxy-tetrahydro-furan-2-ylmethylsulfanyl]-ethyl}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

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Chemical Property of 1-((2R,4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-{2-[(2S,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-4-methoxy-tetrahydro-furan-2-ylmethylsulfanyl]-ethyl}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

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Technology Process of 1-((2R,4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-{2-[(2S,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-4-methoxy-tetrahydro-furan-2-ylmethylsulfanyl]-ethyl}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

There total 11 articles about 1-((2R,4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-{2-[(2S,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-4-methoxy-tetrahydro-furan-2-ylmethylsulfanyl]-ethyl}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 174088-79-0
C₄₉H₆₂N₄O₁₂SSi

: 174088-80-3
1-((2R,4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-{2-[(2S,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-4-methoxy-tetrahydro-furan-2-ylmethylsulfanyl]-ethyl}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: With tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; for 20h; Heating;
DOI:10.1080/15257779508010717

Reference yield:

: 174088-71-2
3-N-(trimethylsilyl)ethoxymethyl-2'-O-methyluridine

: 174088-80-3
1-((2R,4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-{2-[(2S,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-4-methoxy-tetrahydro-furan-2-ylmethylsulfanyl]-ethyl}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 6 steps

1: 62 percent / diisopropyl azodicarboxylate, PPh₃ / tetrahydrofuran / 1.) 0 deg C, 0.5 h, 2.) room temperature, 30 min

2: 98 percent / NH₃ gas / methanol / 20 h

3: 85 percent / CsCO₃ / dimethylformamide / 3 h / Ambient temperature

4: TBAF / tetrahydrofuran / 0.17 h

5: 82 percent / DMAP, Et₃N / pyridine / 8 h

6: 98 percent / Et₃N, TBAF / tetrahydrofuran / 20 h / Heating

With dmap; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; ammonia; triethylamine; triphenylphosphine; In tetrahydrofuran; pyridine; methanol; N,N-dimethyl-formamide;
DOI:10.1080/15257779508010717

Reference yield:

: 174088-73-4
3-N-(trimethylsilyl)ethoxymethyl-2'-O-methyl-5'-deoxy-5'-thiouridine

: 174088-80-3
1-((2R,4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-{2-[(2S,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-4-methoxy-tetrahydro-furan-2-ylmethylsulfanyl]-ethyl}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / CsCO₃ / dimethylformamide / 3 h / Ambient temperature

2: TBAF / tetrahydrofuran / 0.17 h

3: 82 percent / DMAP, Et₃N / pyridine / 8 h

4: 98 percent / Et₃N, TBAF / tetrahydrofuran / 20 h / Heating

With dmap; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; pyridine; N,N-dimethyl-formamide;
DOI:10.1080/15257779508010717