tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-5-methyl-4-oxo-7-phenyl-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}carbamate

Base Information

Chemical Name:tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-5-methyl-4-oxo-7-phenyl-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}carbamate
CAS No.:1349877-61-7
Molecular Formula:C₃₄H₃₆ClN₅O₃
Molecular Weight:598.145
Hs Code.:

Synonyms:tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-5-methyl-4-oxo-7-phenyl-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}carbamate

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Chemical Property of tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-5-methyl-4-oxo-7-phenyl-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}carbamate

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Technology Process of tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-5-methyl-4-oxo-7-phenyl-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}carbamate

There total 8 articles about tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-5-methyl-4-oxo-7-phenyl-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1360573-14-3
C₃₄H₃₇ClIN₅O₃

: 1349877-63-9
tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-5-methyl-4-oxo-9-phenyl-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}carbamate

: 1349877-61-7
tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-5-methyl-4-oxo-7-phenyl-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}carbamate

Guidance literature:: With palladium diacetate; triphenylphosphine; silver carbonate; In N,N-dimethyl-formamide; at 150 ℃; for 1.33333h;
DOI:10.1016/j.tet.2011.10.015

Reference yield:

: 1360573-14-3
C₃₄H₃₇ClIN₅O₃

: 1349877-61-7
tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-5-methyl-4-oxo-7-phenyl-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}carbamate

Guidance literature:: With silver (I) hydrogen carbonate; palladium diacetate; triphenylphosphine; In N,N-dimethyl-formamide; at 150 ℃; for 1h;
DOI:10.1016/j.bmc.2012.07.046

Reference yield:

: C₂₃H₃₂ClIN₄O₄

: 1349877-61-7
tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-5-methyl-4-oxo-7-phenyl-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol; sodium hydroxide / 80 °C

2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 4 h / 0 - 20 °C

2.2: 12 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

4.1: silver (I) hydrogen carbonate; palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 1 h / 150 °C

With oxalyl dichloride; silver (I) hydrogen carbonate; ethanol; palladium diacetate; potassium carbonate; triphenylphosphine; sodium hydroxide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.07.046