(+/-)-8-(4-(ethylsulfonyl)piperazin-1-yl)-5-(4-fluorophenoxy)-2-methyl-2,3,4,5-tetrahydro-1H-benzo[c]azepine

Base Information

Chemical Name:(+/-)-8-(4-(ethylsulfonyl)piperazin-1-yl)-5-(4-fluorophenoxy)-2-methyl-2,3,4,5-tetrahydro-1H-benzo[c]azepine
CAS No.:1084809-89-1
Molecular Formula:C₂₃H₃₀FN₃O₃S
Molecular Weight:447.574
Hs Code.:

Synonyms:(+/-)-8-(4-(ethylsulfonyl)piperazin-1-yl)-5-(4-fluorophenoxy)-2-methyl-2,3,4,5-tetrahydro-1H-benzo[c]azepine

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Chemical Property of (+/-)-8-(4-(ethylsulfonyl)piperazin-1-yl)-5-(4-fluorophenoxy)-2-methyl-2,3,4,5-tetrahydro-1H-benzo[c]azepine

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Technology Process of (+/-)-8-(4-(ethylsulfonyl)piperazin-1-yl)-5-(4-fluorophenoxy)-2-methyl-2,3,4,5-tetrahydro-1H-benzo[c]azepine

There total 6 articles about (+/-)-8-(4-(ethylsulfonyl)piperazin-1-yl)-5-(4-fluorophenoxy)-2-methyl-2,3,4,5-tetrahydro-1H-benzo[c]azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 62937-96-6
1-ethanesulfonylpiperazine

: 1084812-23-6
8-bromo-5-(4-fluorophenoxy)-2-methyl-2,3,4,5-tetrahydro-1H-benzo[c]azepine

: 1084809-89-1
(+/-)-8-(4-(ethylsulfonyl)piperazin-1-yl)-5-(4-fluorophenoxy)-2-methyl-2,3,4,5-tetrahydro-1H-benzo[c]azepine

Guidance literature:: With caesium carbonate; XPhos; palladium diacetate; In toluene; Heating / reflux;

Reference yield:

: 3132-99-8
m-bromobenzoic aldehyde

: 1084809-89-1
(+/-)-8-(4-(ethylsulfonyl)piperazin-1-yl)-5-(4-fluorophenoxy)-2-methyl-2,3,4,5-tetrahydro-1H-benzo[c]azepine

Guidance literature:: Multi-step reaction with 6 steps

1.1: iodine / methanol; water / 0.5 h / 0 °C

1.2: 5 h / 0 °C

2.1: pyridine / 2 h / Heating / reflux

3.1: trifluorormethanesulfonic acid / 72 h / 120 °C

3.2: 0 °C / pH 9

4.1: sodium tetrahydroborate / methanol / 1 h / 0 °C

5.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 5 h / 20 °C

6.1: caesium carbonate; XPhos / palladium diacetate / toluene / Heating / reflux

With pyridine; sodium tetrahydroborate; tributylphosphine; trifluorormethanesulfonic acid; iodine; caesium carbonate; 1,1'-azodicarbonyl-dipiperidine; XPhos; palladium diacetate; In tetrahydrofuran; methanol; water; toluene;

Reference yield:

: 1084811-94-8
C₁₁H₁₄BrNO₂

: 1084809-89-1
(+/-)-8-(4-(ethylsulfonyl)piperazin-1-yl)-5-(4-fluorophenoxy)-2-methyl-2,3,4,5-tetrahydro-1H-benzo[c]azepine

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluorormethanesulfonic acid / 72 h / 120 °C

1.2: 0 °C / pH 9

2.1: sodium tetrahydroborate / methanol / 1 h / 0 °C

3.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 5 h / 20 °C

4.1: caesium carbonate; XPhos / palladium diacetate / toluene / Heating / reflux

With sodium tetrahydroborate; tributylphosphine; trifluorormethanesulfonic acid; caesium carbonate; 1,1'-azodicarbonyl-dipiperidine; XPhos; palladium diacetate; In tetrahydrofuran; methanol; toluene;