1-methyl-N-(4-((2-(2-morpholinoethyl)piperidin-1-yl)sulfonyl)phenyl)-3-(trifluoromethyl)pyrazole-5-carboxamide

Base Information

Chemical Name:1-methyl-N-(4-((2-(2-morpholinoethyl)piperidin-1-yl)sulfonyl)phenyl)-3-(trifluoromethyl)pyrazole-5-carboxamide
CAS No.:1374006-95-7
Molecular Formula:C₂₃H₃₀F₃N₅O₄S
Molecular Weight:529.584
Hs Code.:

Synonyms:1-methyl-N-(4-((2-(2-morpholinoethyl)piperidin-1-yl)sulfonyl)phenyl)-3-(trifluoromethyl)pyrazole-5-carboxamide

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Chemical Property of 1-methyl-N-(4-((2-(2-morpholinoethyl)piperidin-1-yl)sulfonyl)phenyl)-3-(trifluoromethyl)pyrazole-5-carboxamide

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Technology Process of 1-methyl-N-(4-((2-(2-morpholinoethyl)piperidin-1-yl)sulfonyl)phenyl)-3-(trifluoromethyl)pyrazole-5-carboxamide

There total 12 articles about 1-methyl-N-(4-((2-(2-morpholinoethyl)piperidin-1-yl)sulfonyl)phenyl)-3-(trifluoromethyl)pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 1374006-92-4
N-(4-((2-(2-hydroxyethyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

: 1374006-95-7
1-methyl-N-(4-((2-(2-morpholinoethyl)piperidin-1-yl)sulfonyl)phenyl)-3-(trifluoromethyl)pyrazole-5-carboxamide

Guidance literature:: N-(4-((2-(2-hydroxyethyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane;

morpholine; With sodium tris(acetoxy)borohydride; In dichloromethane;

Reference yield:

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

: 1374006-95-7
1-methyl-N-(4-((2-(2-morpholinoethyl)piperidin-1-yl)sulfonyl)phenyl)-3-(trifluoromethyl)pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium carbonate / water; acetone / 0 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide

3.1: palladium on activated charcoal; hydrogen / ethanol / 3 h

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane

5.1: palladium on activated charcoal; hydrogen / ethanol / 3 h / 2068.65 Torr

6.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 0 °C

6.2: 2 h

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran

8.1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / 1 h / -78 °C

9.1: sodium tris(acetoxy)borohydride / dichloromethane / 9 h

With 1H-imidazole; oxalyl dichloride; palladium on activated charcoal; tetrabutyl ammonium fluoride; hydrogen; sodium tris(acetoxy)borohydride; sodium carbonate; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm201699w

Reference yield:

: 153108-98-6
N-<(benzyloxy)carbonyl>-2-<2-(tert-butyldimethylsiloxy)ethyl>piperidine

: 1374006-95-7
1-methyl-N-(4-((2-(2-morpholinoethyl)piperidin-1-yl)sulfonyl)phenyl)-3-(trifluoromethyl)pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: palladium on activated charcoal; hydrogen / ethanol / 3 h

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane

3.1: palladium on activated charcoal; hydrogen / ethanol / 3 h / 2068.65 Torr

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 0 °C

4.2: 2 h

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran

6.1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / 1 h / -78 °C

7.1: sodium tris(acetoxy)borohydride / dichloromethane / 9 h

With oxalyl dichloride; palladium on activated charcoal; tetrabutyl ammonium fluoride; hydrogen; sodium tris(acetoxy)borohydride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm201699w