6-chloro-1,1-bis-(dimethyl-phenyl-silanyl)-4-methoxy-1,3-dihydro-furo[3,4-c]pyridine

Base Information

Chemical Name:6-chloro-1,1-bis-(dimethyl-phenyl-silanyl)-4-methoxy-1,3-dihydro-furo[3,4-c]pyridine
CAS No.:754992-23-9
Molecular Formula:C₂₄H₂₈ClNO₂Si₂
Molecular Weight:454.116
Hs Code.:

6-chloro-1,1-bis-(dimethyl-phenyl-silanyl)-4-methoxy-1,3-dihydro-furo[3,4-<i>c</i>]pyridine

Synonyms:6-chloro-1,1-bis-(dimethyl-phenyl-silanyl)-4-methoxy-1,3-dihydro-furo[3,4-c]pyridine

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Chemical Property of 6-chloro-1,1-bis-(dimethyl-phenyl-silanyl)-4-methoxy-1,3-dihydro-furo[3,4-c]pyridine

Chemical Property:

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Technology Process of 6-chloro-1,1-bis-(dimethyl-phenyl-silanyl)-4-methoxy-1,3-dihydro-furo[3,4-c]pyridine

There total 4 articles about 6-chloro-1,1-bis-(dimethyl-phenyl-silanyl)-4-methoxy-1,3-dihydro-furo[3,4-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 768-33-2
phenyldimethylsilyl chloride

: 754992-22-8
6-chloro-4-methoxy-1,3-dihydro-furo[3,4-c]pyridine

: 754992-23-9
6-chloro-1,1-bis-(dimethyl-phenyl-silanyl)-4-methoxy-1,3-dihydro-furo[3,4-c]pyridine

Guidance literature:: 6-chloro-4-methoxy-1,3-dihydro-furo[3,4-c]pyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h;

phenyldimethylsilyl chloride; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1021/ol0489797

Reference yield:

: 2,6-dichloro-4-(chloromethyl)nicotinoaldehyde

: 754992-23-9
6-chloro-1,1-bis-(dimethyl-phenyl-silanyl)-4-methoxy-1,3-dihydro-furo[3,4-c]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 16 percent / NaBH₄ / ethanol / 0 - 20 °C

2.1: methanol / 12 h / 20 °C

3.1: LDA / tetrahydrofuran / 1 h / -78 °C

3.2: 80 percent / tetrahydrofuran / -78 - 20 °C

With sodium tetrahydroborate; lithium diisopropyl amide; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/ol0489797

Reference yield:

: 754992-21-7
4,6-dichloro-1,3-dihydrofuro[3,4-c]pyridine

: 754992-23-9
6-chloro-1,1-bis-(dimethyl-phenyl-silanyl)-4-methoxy-1,3-dihydro-furo[3,4-c]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / 12 h / 20 °C

2.1: LDA / tetrahydrofuran / 1 h / -78 °C

2.2: 80 percent / tetrahydrofuran / -78 - 20 °C

With lithium diisopropyl amide; In tetrahydrofuran; methanol;
DOI:10.1021/ol0489797