4'-O-methyl-(-)-epicatechin-7-O-β-D-glucuronide

Base Information

• Chemical Name: 4'-O-methyl-(-)-epicatechin-7-O-β-D-glucuronide
• CAS No.: 603133-93-3
• Molecular Formula: C₂₂H₂₄O₁₂
• Molecular Weight: 480.425
• Mol file: 603133-93-3.mol

Synonyms:4'-O-methyl-(-)-epicatechin-7-O-β-D-glucuronide

Chemical Property of 4'-O-methyl-(-)-epicatechin-7-O-β-D-glucuronide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4'-O-methyl-(-)-epicatechin-7-O-β-D-glucuronide

There total 9 articles about 4'-O-methyl-(-)-epicatechin-7-O-β-D-glucuronide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C43H42O12 → 4'-O-methyl-(+)-epicatechin-7-O-β-D-glucuronide + 4'-O-methyl-(-)-epicatechin-7-O-β-D-glucuronide (603133-93-3)

Guidance literature:

With 20 % Pd(OH)2/C; hydrogen; In methanol; for 2h; under 760.051 Torr;

DOI:10.1016/j.tetlet.2012.01.054

Reference yield:

C32H32O7 (1365537-14-9) → 4'-O-methyl-(-)-epicatechin-7-O-β-D-glucuronide (603133-93-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C / Inert atmosphere

1.2: 3 h / 0 - 20 °C / Inert atmosphere

2.1: hydrogenchloride / methanol; dichloromethane; 1,4-dioxane / 2 h / 20 °C / Inert atmosphere

3.1: dichloromethane / 0.75 h / Inert atmosphere; Molecular sieve; Cooling with ice

3.2: 1.5 h / Inert atmosphere; Cooling with ice

4.1: sodium hydroxide / methanol; tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

5.1: 20% palladium hydroxide-activated charcoal; hydrogen / methanol / 1 h / Inert atmosphere

With hydrogenchloride; 20% palladium hydroxide-activated charcoal; hydrogen; sodium hydride; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/np300568m

Reference yield:

C39H38O7 (1365537-15-0) → 4'-O-methyl-(-)-epicatechin-7-O-β-D-glucuronide (603133-93-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogenchloride / methanol; dichloromethane; 1,4-dioxane / 2 h / 20 °C / Inert atmosphere

2.1: dichloromethane / 0.75 h / Inert atmosphere; Molecular sieve; Cooling with ice

2.2: 1.5 h / Inert atmosphere; Cooling with ice

3.1: sodium hydroxide / methanol; tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

4.1: 20% palladium hydroxide-activated charcoal; hydrogen / methanol / 1 h / Inert atmosphere

With hydrogenchloride; 20% palladium hydroxide-activated charcoal; hydrogen; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;

DOI:10.1021/np300568m

upstream raw materials:

methyl 2,3,4-tri-O-acetyl-1-O-(trichloroacetimidoyl)-α-D-glucopyranuronate

C₃₂H₃₂O₇

C₃₉H₃₈O₇

C₃₇H₃₄O₆