Technology Process of 4-(tert-butyl)-2-(p-tolyl)pyridine
There total 9 articles about 4-(tert-butyl)-2-(p-tolyl)pyridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
para-bromotoluene;
With
lithium;
In
diethyl ether;
at 20 ℃;
Inert atmosphere;
4-tert-butylpyridine;
In
diethyl ether; cyclohexane;
at 20 ℃;
for 22h;
Inert atmosphere;
Reflux;
DOI:10.1039/b820426h
- Guidance literature:
-
With
bis(benzonitrile)palladium(II) dichloride; cetyltrimethylammonim bromide; potassium pivalate; triphenylphosphine; copper(I) bromide;
In
N,N-dimethyl acetamide;
at 120 ℃;
for 16h;
Schlenk technique;
Sealed tube;
Inert atmosphere;
DOI:10.1021/acs.joc.9b02694
- Guidance literature:
-
Multi-step reaction with 3 steps
1: silver nitrate; ammonium peroxydisulfate / 1,2-dichloro-ethane; water / 2 h / 50 °C
2: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.5 h / 25 °C
3: silver nitrate; ammonium peroxydisulfate; trifluoroacetic acid / water; dichloromethane / 3 h / 25 °C
With
ammonium peroxydisulfate; silver nitrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid;
In
dichloromethane; water; 1,2-dichloro-ethane;
1: |Minisci Aromatic Substitution / 3: |Minisci Aromatic Substitution;
DOI:10.1021/jacs.1c05278
