N-Benzoyl-N-(9-{3-[1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-prop-2-ynyl}-9H-purin-6-yl)-benzamide

Base Information

Chemical Name:N-Benzoyl-N-(9-{3-[1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-prop-2-ynyl}-9H-purin-6-yl)-benzamide
CAS No.:176548-62-2
Molecular Formula:C₃₁H₂₅N₇O₇
Molecular Weight:607.582
Hs Code.:

N-Benzoyl-N-(9-{3-[1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-prop-2-ynyl}-9H-purin-6-yl)-benzamide

Synonyms:N-Benzoyl-N-(9-{3-[1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-prop-2-ynyl}-9H-purin-6-yl)-benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-Benzoyl-N-(9-{3-[1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-prop-2-ynyl}-9H-purin-6-yl)-benzamide

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of N-Benzoyl-N-(9-{3-[1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-prop-2-ynyl}-9H-purin-6-yl)-benzamide

There total 4 articles about N-Benzoyl-N-(9-{3-[1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-prop-2-ynyl}-9H-purin-6-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 54-42-2,162239-35-2
5-Iodo-2'-deoxyuridine

: 176548-62-2
N-Benzoyl-N-(9-{3-[1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-prop-2-ynyl}-9H-purin-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.09 g / CH₂Cl₂ / Ambient temperature

2: 977 mg / CuI, Et₃N / Pd(PPh₃)4 / dimethylformamide / 48 h / Ambient temperature

With copper(l) iodide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0960-894X(96)00112-6

Reference yield:

: 66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9
adenine

: 176548-62-2
N-Benzoyl-N-(9-{3-[1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-prop-2-ynyl}-9H-purin-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / K₂CO₃ / dimethylformamide

2: 65 percent / pyridine / 1) 0 deg C -> room temperature, 2) room temperature, 6 h

3: 977 mg / CuI, Et₃N / Pd(PPh₃)4 / dimethylformamide / 48 h / Ambient temperature

With pyridine; copper(l) iodide; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide;
DOI:10.1016/0960-894X(96)00112-6

Reference yield:

: 148238-36-2
N-9-propargyladenine

: 176548-62-2
N-Benzoyl-N-(9-{3-[1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-prop-2-ynyl}-9H-purin-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / pyridine / 1) 0 deg C -> room temperature, 2) room temperature, 6 h

2: 977 mg / CuI, Et₃N / Pd(PPh₃)4 / dimethylformamide / 48 h / Ambient temperature

With pyridine; copper(l) iodide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide;
DOI:10.1016/0960-894X(96)00112-6