Benzyl ((2R)-N-benzyloxycarbonyl-α-methyl aspartyl)-β-(2S)-phenylalaninyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-glycinate triester

Base Information

Chemical Name:Benzyl ((2R)-N-benzyloxycarbonyl-α-methyl aspartyl)-β-(2S)-phenylalaninyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-glycinate triester
CAS No.:196938-82-6
Molecular Formula:C₄₀H₄₇N₅O₁₂
Molecular Weight:789.839
Hs Code.:

Synonyms:Benzyl ((2R)-N-benzyloxycarbonyl-α-methyl aspartyl)-β-(2S)-phenylalaninyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-glycinate triester

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Chemical Property of Benzyl ((2R)-N-benzyloxycarbonyl-α-methyl aspartyl)-β-(2S)-phenylalaninyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-glycinate triester

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Technology Process of Benzyl ((2R)-N-benzyloxycarbonyl-α-methyl aspartyl)-β-(2S)-phenylalaninyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-glycinate triester

There total 14 articles about Benzyl ((2R)-N-benzyloxycarbonyl-α-methyl aspartyl)-β-(2S)-phenylalaninyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-glycinate triester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35793-73-8
N-(tert-butyloxycarbonyl)-γ-benzyl-D-glutamic acid

: 196938-82-6
Benzyl ((2R)-N-benzyloxycarbonyl-α-methyl aspartyl)-β-(2S)-phenylalaninyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-glycinate triester

Guidance literature:: Multi-step reaction with 8 steps

1: 100 percent / diethyl ether / 0.5 h / 0 °C

2: 100 percent / H₂ / 10percent Pd/C / ethanol / 3 h / Ambient temperature

3: 4-methylmorpholine / tetrahydrofuran / 0.08 h / -15 °C

4: 4-methylmorpholine / dimethylformamide; tetrahydrofuran / 0.42 h / Ambient temperature

5: 90 percent / HCl / ethyl acetate / 1.5 h / Ambient temperature

6: 4-methylmorpholine / tetrahydrofuran; dimethylformamide / 0.5 h / Ambient temperature

7: 90 percent / HCl / ethyl acetate / 1.5 h / Ambient temperature

8: N-methylmorpholine / dimethylformamide; tetrahydrofuran / 2 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 110473-10-4
N-Boc-D-Glu α-methyl ester

: 196938-82-6
Benzyl ((2R)-N-benzyloxycarbonyl-α-methyl aspartyl)-β-(2S)-phenylalaninyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-glycinate triester

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / H₂ / 10percent Pd/C / ethanol / 3 h / Ambient temperature

2: 4-methylmorpholine / tetrahydrofuran / 0.08 h / -15 °C

3: 4-methylmorpholine / dimethylformamide; tetrahydrofuran / 0.42 h / Ambient temperature

4: 90 percent / HCl / ethyl acetate / 1.5 h / Ambient temperature

5: 4-methylmorpholine / tetrahydrofuran; dimethylformamide / 0.5 h / Ambient temperature

6: 90 percent / HCl / ethyl acetate / 1.5 h / Ambient temperature

7: N-methylmorpholine / dimethylformamide; tetrahydrofuran / 2 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 135841-16-6
(R)-3-benzyloxycarbonyl-5-oxo-4-oxazolidinoneacetic acid

: 196938-82-6
Benzyl ((2R)-N-benzyloxycarbonyl-α-methyl aspartyl)-β-(2S)-phenylalaninyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-glycinate triester

Guidance literature:: Multi-step reaction with 7 steps

1: N-methylmorpholine / tetrahydrofuran / 0.08 h / -15 °C

2: N-methylmorpholine / tetrahydrofuran / 0.5 h / Ambient temperature

3: aq. NaOH / methanol / 1 h / Ambient temperature

4: diethyl ether / 0.5 h / 0 °C

5: 73 percent / TFA / CH₂Cl₂ / 4 h / Ambient temperature

6: N-methylmorpholine / tetrahydrofuran / 0.08 h / -15 °C

7: N-methylmorpholine / dimethylformamide; tetrahydrofuran / 2 h / Ambient temperature

With 4-methyl-morpholine; sodium hydroxide; trifluoroacetic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;