(E)-ethyl 5-((2,5-dimethyl-1-(2-(trifluoromethyl)phenyl)-1H-pyrrol-3-yl)methylene)-2-methyl-4-oxo-4,5-dihydro-1H-pyrrole-3-carboxylate

Base Information

• Chemical Name: (E)-ethyl 5-((2,5-dimethyl-1-(2-(trifluoromethyl)phenyl)-1H-pyrrol-3-yl)methylene)-2-methyl-4-oxo-4,5-dihydro-1H-pyrrole-3-carboxylate
• CAS No.: 1428183-45-2
• Molecular Formula: C₂₂H₂₁F₃N₂O₃
• Molecular Weight: 418.416
• Mol file: 1428183-45-2.mol

Synonyms:(E)-ethyl 5-((2,5-dimethyl-1-(2-(trifluoromethyl)phenyl)-1H-pyrrol-3-yl)methylene)-2-methyl-4-oxo-4,5-dihydro-1H-pyrrole-3-carboxylate

Chemical Property of (E)-ethyl 5-((2,5-dimethyl-1-(2-(trifluoromethyl)phenyl)-1H-pyrrol-3-yl)methylene)-2-methyl-4-oxo-4,5-dihydro-1H-pyrrole-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-ethyl 5-((2,5-dimethyl-1-(2-(trifluoromethyl)phenyl)-1H-pyrrol-3-yl)methylene)-2-methyl-4-oxo-4,5-dihydro-1H-pyrrole-3-carboxylate

There total 6 articles about (E)-ethyl 5-((2,5-dimethyl-1-(2-(trifluoromethyl)phenyl)-1H-pyrrol-3-yl)methylene)-2-methyl-4-oxo-4,5-dihydro-1H-pyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

ethyl 5-methyl-3-oxo-1,2-dihydropyrrole-4-carboxylate (65713-63-5) + 2,5-dimethyl-1-(2-(trifluoromethyl)phenyl)-1H-pyrrole-3-carbaldehyde (932226-24-9) → (E)-ethyl 5-((2,5-dimethyl-1-(2-(trifluoromethyl)phenyl)-1H-pyrrol-3-yl)methylene)-2-methyl-4-oxo-4,5-dihydro-1H-pyrrole-3-carboxylate (1428183-45-2)

Guidance literature:

With potassium hydrogensulfate; In ethanol; at 70 - 80 ℃; for 3h;

DOI:10.1021/jm400009c

Reference yield:

ethyl aminocrotonate (626-34-6,7318-00-5,41867-20-3) → (E)-ethyl 5-((2,5-dimethyl-1-(2-(trifluoromethyl)phenyl)-1H-pyrrol-3-yl)methylene)-2-methyl-4-oxo-4,5-dihydro-1H-pyrrole-3-carboxylate (1428183-45-2)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / diethyl ether / 3.5 h / 0 °C

2: potassium hydroxide / ethanol / 3 h / 0 °C

3: potassium hydrogensulfate / ethanol / 3 h / 70 - 80 °C

With pyridine; potassium hydrogensulfate; potassium hydroxide; In diethyl ether; ethanol;

DOI:10.1021/jm400009c

Reference yield:

(E)-ethyl 3-amino-2-(2-chloroacetyl)but-2-enoate (78120-39-5) → (E)-ethyl 5-((2,5-dimethyl-1-(2-(trifluoromethyl)phenyl)-1H-pyrrol-3-yl)methylene)-2-methyl-4-oxo-4,5-dihydro-1H-pyrrole-3-carboxylate (1428183-45-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 3 h / 0 °C

2: potassium hydrogensulfate / ethanol / 3 h / 70 - 80 °C

With potassium hydrogensulfate; potassium hydroxide; In ethanol;

DOI:10.1021/jm400009c

upstream raw materials:

ethyl 5-methyl-3-oxo-1,2-dihydropyrrole-4-carboxylate

2,5-dimethyl-1-(2-(trifluoromethyl)phenyl)-1H-pyrrole-3-carbaldehyde

2,5-hexanedione

2-(trifluoromethyl)benzenamine

Downstream raw materials:

C₂₂H₂₃F₃N₂O₃

C₂₃H₂₃F₃N₂O₃