m thyl 2-deoxy-6-O-p-tolylsulfonyl-α-D-arabino-hexofuranoside

Base Information

• Chemical Name: m thyl 2-deoxy-6-O-p-tolylsulfonyl-α-D-arabino-hexofuranoside
• CAS No.: 88756-98-3
• Molecular Formula: C₁₄H₂₀O₇S
• Molecular Weight: 332.375
• Mol file: 88756-98-3.mol

Synonyms:m thyl 2-deoxy-6-O-p-tolylsulfonyl-α-D-arabino-hexofuranoside

Chemical Property of m thyl 2-deoxy-6-O-p-tolylsulfonyl-α-D-arabino-hexofuranoside

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of m thyl 2-deoxy-6-O-p-tolylsulfonyl-α-D-arabino-hexofuranoside

There total 1 articles about m thyl 2-deoxy-6-O-p-tolylsulfonyl-α-D-arabino-hexofuranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

p-toluenesulfonyl chloride (98-59-9) + methyl 2-deoxy-α-D-arabino-hexofuranoside (6001-17-8) → m thyl 2-deoxy-6-O-p-tolylsulfonyl-α-D-arabino-hexofuranoside (88756-98-3)

Guidance literature:

With pyridine; at 0 ℃; for 12h;

DOI:10.1016/0008-6215(83)88365-7

Reference yield:

m thyl 2-deoxy-6-O-p-tolylsulfonyl-α-D-arabino-hexofuranoside (88756-98-3) → 3,5-di-O-benzoyl-2,6-dideoxy-L-lyxo-hexofuranosil chloride (88757-02-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 77 percent / LiAlH₄ / tetrahydrofuran / 1.) r.t., 12 h; 2.) reflux, 2 h

2: 100 percent / CH₂Cl₂; triethylamine / 0.33 h / 0 °C

3: 77 percent / benzene / 6 h / Heating

4: HCl, acetic acide / diethyl ether / 0.5 h / 0 °C

With hydrogenchloride; lithium aluminium tetrahydride; acetic acid; In tetrahydrofuran; diethyl ether; dichloromethane; triethylamine; benzene;

DOI:10.1016/0008-6215(83)88365-7

Reference yield:

m thyl 2-deoxy-6-O-p-tolylsulfonyl-α-D-arabino-hexofuranoside (88756-98-3) → methyl 3,5-di-O-benzoyl-2,6-dideoxy-β-L-lyxo-hexofuranoside (88757-01-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 77 percent / LiAlH₄ / tetrahydrofuran / 1.) r.t., 12 h; 2.) reflux, 2 h

2: 100 percent / CH₂Cl₂; triethylamine / 0.33 h / 0 °C

3: 77 percent / benzene / 6 h / Heating

With lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane; triethylamine; benzene;

DOI:10.1016/0008-6215(83)88365-7

upstream raw materials:

p-toluenesulfonyl chloride

methyl 2-deoxy-α-D-arabino-hexofuranoside

Downstream raw materials:

3,5-di-O-benzoyl-2,6-dideoxy-L-lyxo-hexofuranosil chloride

methyl 3,5-di-O-benzoyl-2,6-dideoxy-β-L-lyxo-hexofuranoside

9-(3,5-di-O-benzoyl-2,6-dideoxy-α,β-L-lyxo-hexofuranosil)hypoxanthine