(R)-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetylamino)acetic acid pentafluorophenyl ester

Base Information

Chemical Name:(R)-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetylamino)acetic acid pentafluorophenyl ester
CAS No.:550377-02-1
Molecular Formula:C₂₁H₂₅F₅N₂O₅
Molecular Weight:480.432
Hs Code.:

Synonyms:(R)-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetylamino)acetic acid pentafluorophenyl ester

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Chemical Property of (R)-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetylamino)acetic acid pentafluorophenyl ester

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Technology Process of (R)-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetylamino)acetic acid pentafluorophenyl ester

There total 3 articles about (R)-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetylamino)acetic acid pentafluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14533-84-7
pentafluorophenyl trifloroacetate

: 289055-33-0
(2-tert-butoxycarbonylamino-2-cyclohexyl-acetylamino)-acetic acid

: 550377-02-1
(R)-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetylamino)acetic acid pentafluorophenyl ester

Guidance literature:: With pyridine; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jm049967u

Reference yield:

: 70491-05-3
(2R)-[(tert-butoxycarbonyl)-amino](cyclohexyl)ethanoic acid

: 550377-02-1
(R)-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetylamino)acetic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: EDC; HOBt monohydrate; triethylamine / CH₂Cl₂ / 20 °C

2: aq. LiOH / tetrahydrofuran / 20 °C

3: pyridine / tetrahydrofuran / 2 h / 20 °C

With pyridine; lithium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm049967u

Reference yield:

: 550378-29-5
(2-tert-butoxycarbonylamino-2-cyclohexyl-acetylamino)-acetic acid methyl ester

: 550377-02-1
(R)-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetylamino)acetic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: aq. LiOH / tetrahydrofuran / 20 °C

2: pyridine / tetrahydrofuran / 2 h / 20 °C

With pyridine; lithium hydroxide; In tetrahydrofuran;
DOI:10.1021/jm049967u