2-{4-[3-(2-methylpyrrolidin-1-yl)propoxy]phenyl}-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine

Base Information

Chemical Name:2-{4-[3-(2-methylpyrrolidin-1-yl)propoxy]phenyl}-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine
CAS No.:1004762-61-1
Molecular Formula:C₂₀H₂₇N₃OS
Molecular Weight:357.52
Hs Code.:

Synonyms:2-{4-[3-(2-methylpyrrolidin-1-yl)propoxy]phenyl}-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine

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Chemical Property of 2-{4-[3-(2-methylpyrrolidin-1-yl)propoxy]phenyl}-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine

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Technology Process of 2-{4-[3-(2-methylpyrrolidin-1-yl)propoxy]phenyl}-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine

There total 4 articles about 2-{4-[3-(2-methylpyrrolidin-1-yl)propoxy]phenyl}-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1004764-02-6
2-{4-[(3-chloropropyl)oxy]phenyl}-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine

: 765-38-8
2-methyl-1-pyrrolidine

: 1004762-61-1
2-{4-[3-(2-methylpyrrolidin-1-yl)propoxy]phenyl}-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine

Guidance literature:: With potassium carbonate; sodium iodide; In acetonitrile; at 90 ℃; for 60h;

Reference yield:

: 911134-67-3
4-(3-chloropropoxy)benzenecarbothioamide

: 1004762-61-1
2-{4-[3-(2-methylpyrrolidin-1-yl)propoxy]phenyl}-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: isopropyl alcohol / 1 h / 90 °C

2: sodium iodide / acetonitrile / 24 h / 90 °C

With isopropyl alcohol; sodium iodide; In acetonitrile; 1: Hantzsch condensation;
DOI:10.1002/cmdc.201100248

Reference yield:

: 619-57-8
p-hydroxybenzamide

: 1004762-61-1
2-{4-[3-(2-methylpyrrolidin-1-yl)propoxy]phenyl}-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / ethyl acetate / 24 h / Reflux

2: Lawessons reagent / chloroform / 12 h / 22 °C

3: isopropyl alcohol / 1 h / 90 °C

4: sodium iodide / acetonitrile / 24 h / 90 °C

With Lawessons reagent; potassium carbonate; isopropyl alcohol; sodium iodide; In chloroform; ethyl acetate; acetonitrile; 3: Hantzsch condensation;
DOI:10.1002/cmdc.201100248