N-(4-fluoro-3-trifluoromethyl-benzyl)-N-(3-methyl-benzo[b]thiophen-2-yl)-3-carbomethoxy-propanesulfonamide

Base Information

• Chemical Name: N-(4-fluoro-3-trifluoromethyl-benzyl)-N-(3-methyl-benzo[b]thiophen-2-yl)-3-carbomethoxy-propanesulfonamide
• CAS No.: 1104626-10-9
• Molecular Formula: C₂₂H₂₁F₄NO₄S₂
• Molecular Weight: 503.539

Synonyms:N-(4-fluoro-3-trifluoromethyl-benzyl)-N-(3-methyl-benzo[b]thiophen-2-yl)-3-carbomethoxy-propanesulfonamide

Chemical Property of N-(4-fluoro-3-trifluoromethyl-benzyl)-N-(3-methyl-benzo[b]thiophen-2-yl)-3-carbomethoxy-propanesulfonamide

Chemical Property:

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Technology Process of N-(4-fluoro-3-trifluoromethyl-benzyl)-N-(3-methyl-benzo[b]thiophen-2-yl)-3-carbomethoxy-propanesulfonamide

There total 2 articles about N-(4-fluoro-3-trifluoromethyl-benzyl)-N-(3-methyl-benzo[b]thiophen-2-yl)-3-carbomethoxy-propanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(3-methyl-benzo[b]thiophen-2-yl)-3-carbomethoxy-propanesulfonamide (1104631-05-1) + 4-fluoro-3-trifluoromethylbenzyl bromide (184970-26-1) → N-(4-fluoro-3-trifluoromethyl-benzyl)-N-(3-methyl-benzo[b]thiophen-2-yl)-3-carbomethoxy-propanesulfonamide (1104626-10-9)

Guidance literature:

N-(3-methyl-benzo[b]thiophen-2-yl)-3-carbomethoxy-propanesulfonamide; With potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

4-fluoro-3-trifluoromethylbenzyl bromide; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 48h;

Reference yield:

2-Amino-3-methyl-benzo thiophen (13584-55-9) + methyl 4-(4-chlorosulfonyl)butyrate (81926-28-5) → N-(4-fluoro-3-trifluoromethyl-benzyl)-N-(3-methyl-benzo[b]thiophen-2-yl)-3-carbomethoxy-propanesulfonamide (1104626-10-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine / dichloromethane / 48 h / -10 - 20 °C

2.1: potassium tert-butylate / N,N-dimethyl-formamide; tetrahydrofuran / 0.25 h / 0 °C

2.2: 48 h / 20 °C

With pyridine; potassium tert-butylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

N-(3-methyl-benzo[b]thiophen-2-yl)-3-carbomethoxy-propanesulfonamide

4-fluoro-3-trifluoromethylbenzyl bromide

2-Amino-3-methyl-benzo thiophen

methyl 4-(4-chlorosulfonyl)butyrate

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