N-((1R,2R)-2-{5-chloro-2-[8-methoxy-3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)-N-ethylmethanesulfonamide

Base Information

Chemical Name:N-((1R,2R)-2-{5-chloro-2-[8-methoxy-3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)-N-ethylmethanesulfonamide
CAS No.:1022955-52-7
Molecular Formula:C₂₇H₄₁ClN₆O₄S
Molecular Weight:581.179
Hs Code.:

N-((1R,2R)-2-{5-chloro-2-[8-methoxy-3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)-N-ethylmethanesulfonamide

Synonyms:N-((1R,2R)-2-{5-chloro-2-[8-methoxy-3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)-N-ethylmethanesulfonamide

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Chemical Property of N-((1R,2R)-2-{5-chloro-2-[8-methoxy-3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)-N-ethylmethanesulfonamide

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Technology Process of N-((1R,2R)-2-{5-chloro-2-[8-methoxy-3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)-N-ethylmethanesulfonamide

There total 4 articles about N-((1R,2R)-2-{5-chloro-2-[8-methoxy-3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)-N-ethylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1022960-31-1
8-methoxy-3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamine

: 1022955-46-9
C₁₃H₂₀Cl₂N₄O₂S

: 1022955-52-7
N-((1R,2R)-2-{5-chloro-2-[8-methoxy-3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)-N-ethylmethanesulfonamide

Guidance literature:: With camphor-10-sulfonic acid; In isopropyl alcohol; at 120 ℃; for 2h; Microwave irradiation;
DOI:10.1016/j.bmcl.2011.05.040

Reference yield:

: 1022950-54-4
N-[(1R,2R)-2-(2,5-dichloro-pyrimidin-4-ylamino)cyclohexyl]methanesulfonamide

: 1022955-52-7
N-((1R,2R)-2-{5-chloro-2-[8-methoxy-3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)-N-ethylmethanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / acetone / 0.25 h

1.2: 4.5 h / 20 °C

2.1: camphor-10-sulfonic acid / isopropyl alcohol / 2 h / 120 °C / Microwave irradiation

With camphor-10-sulfonic acid; caesium carbonate; In isopropyl alcohol; acetone;
DOI:10.1016/j.bmcl.2011.05.040

Reference yield:

: 1245830-90-3
(1R,2R)-N-(2,5-dichloro-pyrimidin-4-yl)cyclohexane-1,2-diamine

: 1022955-52-7
N-((1R,2R)-2-{5-chloro-2-[8-methoxy-3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)-N-ethylmethanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 0.08 h / 0 °C

2.1: caesium carbonate / acetone / 0.25 h

2.2: 4.5 h / 20 °C

3.1: camphor-10-sulfonic acid / isopropyl alcohol / 2 h / 120 °C / Microwave irradiation

With camphor-10-sulfonic acid; caesium carbonate; triethylamine; In tetrahydrofuran; isopropyl alcohol; acetone;
DOI:10.1016/j.bmcl.2011.05.040