MK-1029

Base Information

Chemical Name:MK-1029
CAS No.:1242272-15-6
Molecular Formula:C₂₃H₂₀F₂N₄O₂
Molecular Weight:422.434
Hs Code.:

Synonyms:MK-1029

Suppliers and Price of MK-1029

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of MK-1029

Chemical Property:

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Technology Process of MK-1029

There total 11 articles about MK-1029 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1242273-06-8
(7R)-4-fluoro-7-[5-[(4-fluorophenyl)methyl]-1H-1,2,3-triazol-1-yl]-6,7,8,9-tetrahydro-pyrido[1,2-a]indole-10-acetic acid ethyl ester

: 1242272-15-6
MK-1029

Guidance literature:: With water; sodium hydroxide; In ethanol; toluene; at 50 ℃; for 2.5h;
DOI:10.1021/acs.oprd.1c00128

Reference yield:

: 133218-06-1
4-fluoro-1-[3-(trimethylsilyl)prop-2-yn-1-yl]benzene

: 1242272-15-6
MK-1029

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; tetramethylammonium fluoride / N,N-dimethyl-formamide / 0 - 5 °C

2: chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II) / toluene / 13.25 h / 70 - 90 °C / Inert atmosphere

3: sodium hydroxide; water / ethanol; toluene / 2.5 h / 50 °C

With chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); tetramethylammonium fluoride; water; acetic acid; sodium hydroxide; In ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/acs.oprd.1c00128

Reference yield:

: 6317-49-3
4-oxopimelate

: 1242272-15-6
MK-1029

Guidance literature:: Multi-step reaction with 9 steps

1.1: toluene-4-sulfonic acid / ethanol / 18 h / Inert atmosphere; Reflux

2.1: acetic acid / 123 - 145 °C / Inert atmosphere

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; N-Methyldicyclohexylamine / 16 h / 100 °C / Inert atmosphere

4.1: potassium tert-butylate / tetrahydrofuran / 2 h / 66 °C / Inert atmosphere

4.2: 2.5 h / 60 °C / Inert atmosphere

5.1: bis(1,5-cyclooctadiene)diiridium(I) dichloride / toluene; N,N-dimethyl-formamide / 1.58 h / 100 °C / Inert atmosphere

6.1: CDX ketoreductase P₃H₂; NADP / aq. phosphate buffer; isopropyl alcohol / 20 h / 33 - 35 °C / pH 7.0 / Inert atmosphere; Enzymatic reaction

7.1: triethylamine; sodium azide / N,N-dimethyl-formamide / 18 h / 70 °C / Inert atmosphere

8.1: chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II) / toluene / 13.25 h / 70 - 90 °C / Inert atmosphere

9.1: sodium hydroxide; water / ethanol; toluene / 2.5 h / 50 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(1,5-cyclooctadiene)diiridium(I) dichloride; sodium azide; chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); N-Methyldicyclohexylamine; potassium tert-butylate; water; CDX ketoreductase P₃H₂; NADP; toluene-4-sulfonic acid; acetic acid; triethylamine; sodium hydroxide; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; aq. phosphate buffer; ethanol; N,N-dimethyl-formamide; isopropyl alcohol; toluene;
DOI:10.1021/acs.oprd.1c00128