4-(2,6-difluorophenyl)-2,4-dioxobutyric acid ethyl ester

Base Information

• Chemical Name: 4-(2,6-difluorophenyl)-2,4-dioxobutyric acid ethyl ester
• CAS No.: 1019340-47-6
• Molecular Formula: C₁₂H₁₀F₂O₄
• Molecular Weight: 256.206
• Mol file: 1019340-47-6.mol

Synonyms:4-(2,6-difluorophenyl)-2,4-dioxobutyric acid ethyl ester

Chemical Property of 4-(2,6-difluorophenyl)-2,4-dioxobutyric acid ethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-(2,6-difluorophenyl)-2,4-dioxobutyric acid ethyl ester

There total 2 articles about 4-(2,6-difluorophenyl)-2,4-dioxobutyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

→ 4-(2,6-difluorophenyl)-2,4-dioxobutyric acid ethyl ester (1019340-47-6)

Guidance literature:

With ethanol; sodium; In diethyl ether; at 23 ℃; for 72h;

Reference yield:

2,6-difluoroacetophenone (13670-99-0) + oxalic acid diethyl ester (95-92-1) → 4-(2,6-difluorophenyl)-2,4-dioxobutyric acid ethyl ester (1019340-47-6)

Guidance literature:

2,6-difluoroacetophenone; With lithium hexamethyldisilazane; at 0 ℃; for 0.5h;

oxalic acid diethyl ester; at 20 ℃;

DOI:10.3390/molecules23082002

Reference yield:

4-(2,6-difluorophenyl)-2,4-dioxobutyric acid ethyl ester (1019340-47-6) → C12H10F2N2O2

Guidance literature:

With hydrazine hydrate; In ethanol; for 2h;

DOI:10.3390/molecules23082002

upstream raw materials:

2,6-difluoroacetophenone

oxalic acid diethyl ester