C₃₂H₃₄N₄O₈

Base Information

• Chemical Name: C₃₂H₃₄N₄O₈
• CAS No.: 1400590-71-7
• Molecular Formula: C₃₂H₃₄N₄O₈
• Molecular Weight: 602.644
• Mol file: 1400590-71-7.mol

Synonyms:C₃₂H₃₄N₄O₈

Chemical Property of C₃₂H₃₄N₄O₈

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₂H₃₄N₄O₈

There total 3 articles about C₃₂H₃₄N₄O₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carboxylic acid tert-butyl ester (917081-57-3) + 1,2-bis-(3-bromo-1-propynyl)benzene (173382-69-9) → C32H34N4O8 (1400590-71-7)

Guidance literature:

5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carboxylic acid tert-butyl ester; With caesium carbonate; In acetonitrile; at 20 ℃; for 0.5h; Inert atmosphere;

1,2-bis-(3-bromo-1-propynyl)benzene; In acetonitrile; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1016/j.tet.2012.07.093

Reference yield:

1,2-bis(1-methylsulfonyloxyprop-1-yn-1-yl)benzene (116510-22-6) → C32H34N4O8 (1400590-71-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium bromide / tetrahydrofuran / 10 h / 0 - 20 °C / Inert atmosphere

2.1: caesium carbonate / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

2.2: 6 h / 20 °C / Inert atmosphere

With caesium carbonate; lithium bromide; In tetrahydrofuran; acetonitrile;

DOI:10.1016/j.tet.2012.07.093

Reference yield:

2,3-dibromobenzene (583-53-9) → C32H34N4O8 (1400590-71-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-butylamine / 80 - 85 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

3.1: lithium bromide / tetrahydrofuran / 10 h / 0 - 20 °C / Inert atmosphere

4.1: caesium carbonate / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

4.2: 6 h / 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; N-butylamine; triethylamine; lithium bromide; In tetrahydrofuran; dichloromethane; acetonitrile; 1.1: |Sonogashira Cross-Coupling;

DOI:10.1016/j.tet.2012.07.093

upstream raw materials:

1,2-bis(1-methylsulfonyloxyprop-1-yn-1-yl)benzene

5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carboxylic acid tert-butyl ester

1,2-bis-(3-bromo-1-propynyl)benzene

2,3-dibromobenzene

Downstream raw materials:

C₂₂H₁₈N₄O₄

Refernces