Cefoperazonum

Base Information

• Chemical Name: Cefoperazonum
• CAS No.: 62893-20-3
• Molecular Formula: C25H27N9O8S2. Na
• Molecular Weight: 667.659
• Hs Code.: 29419000
• NSC Number: 758173
• DSSTox Substance ID: DTXSID50860777
• ChEMBL ID: CHEMBL1331919
• Mol file: 62893-20-3.mol

Synonyms:Céfobis;Cefobid;Cefoperazon;Cefoperazone;Cefoperazone Sodium;Cefoperazone Sodium Salt;Salt, Cefoperazone Sodium;Sodium Salt, Cefoperazone;Sodium, Cefoperazone;T 1551;T-1551;T1551

Chemical Property of Cefoperazonum

Chemical Property:

• Appearance/Colour: Faint beige powder
• Melting Point: 200-202 °C
• PSA: 273.69000
• LogP: -1.85120
• Storage Temp.: 2-8°C
• Solubility.: H2O: 50 mg/mL, clear, faintly yellow
• Water Solubility.: Soluble in water. Slightly soluble in alcohol.
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 13
• Rotatable Bond Count: 9
• Exact Mass: 645.14240120
• Heavy Atom Count: 44
• Complexity: 1250

Purity/Quality:

99% ^*data from raw suppliers

Cefoperazone sodium salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 42/43
• Safety Statements: 22-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN1CCN(C(=O)C1=O)C(=O)NC(C2=CC=C(C=C2)O)C(=O)NC3C4N(C3=O)C(=C(CS4)CSC5=NN=NN5C)C(=O)O
• Uses: Broad spectrum third generation cephalosporin antibiotic. An antibacterial. antidepressant, serotonin reuptake inhibitor, 5HT1A agonist For studying the expression, binding, and inhibition of penicillin-binding proteins.Cefoperazone sodium salt is used in the study of drug-protein binding, expression and inhibition of penicillin-binding proteins during cell wall synthesis. It is as an antibacterial and antimicrobial agent useful for prevention of postoperative infection. It is used as an inhibitor of inactivation of alfa-antitrypsin.
• Therapeutic Function: Antibiotic
• Clinical Use: Cefoperazone sodium is a third-generation, antipseudomonalcephalosporin that resembles piperacillinchemically and microbiologically. It is active against manystrains of P. aeruginosa, indole-positive Proteus spp.,Enterobacter spp., and S. marcescens that are resistant tocefamandole. It is less active than cephalothin againstGram-positive bacteria and less active than cefamandoleagainst most of the Enterobacteriaceae. Like piperacillin,cefoperazone is hydrolyzed by many of the β-lactamasesthat hydrolyze penicillins. Unlike piperacillin, however, itis resistant to some (but not all) of the β-lactamases thathydrolyze cephalosporins.Cefoperazone is excreted primarily in the bile. Hepaticdysfunction can affect its clearance from the body.

Technology Process of Cefoperazonum

There total 3 articles about Cefoperazonum which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.1%

cefoperazone (62893-19-0,68779-10-2) → Cefobis (62893-20-3)

Guidance literature:

With sodium hydrogencarbonate; In water; acetone; at 15 - 25 ℃; for 0.666667h; pH=6.5 - 6.6;

Reference yield:

7-Aminocephalosporanic acid (957-68-6) → Cefobis (62893-20-3)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine; titanium tetrachloride; tetrabutoxytitanium / acetonitrile / 3 h / 5 - 30 °C

2: chloro-trimethyl-silane / N,N-dimethyl-formamide / 4 h / -25 - -20 °C

3: sodium isooctanoate; pyrographite / acetone / 25 °C / pH 6.6

With pyridine; tetrabutoxytitanium; chloro-trimethyl-silane; sodium isooctanoate; titanium tetrachloride; pyrographite; In N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

→ Cefobis (62893-20-3)

Guidance literature:

upstream raw materials:

cefoperazone

7-Aminocephalosporanic acid

Downstream raw materials:

C₂₅H₂₆N₉O₈S₂^(1-)*Cd⁽²⁺⁾*Cl^(1-)

C₂₅H₂₆N₉O₈S₂^(1-)*Fe⁽²⁺⁾*Cl^(1-)

Refernces

• 1、 -. "Cefoperazone sodium compound prepared by using fluid mechanics principle and preparation comprising cefoperazone sodium compound". Paragraph 0025; 0026; 0037; 0038; 0039-0044; 0054-0057. . Retrieved 2017/05/12.
• 2、 -. "A NEW CRYSTAL FORM OF CEFOPERAZONE SODIUM". Page/Page column 6; 7. . Retrieved 2014/02/15.