(+/-)-3-<3-(sec-butylamino)prop-1-yl>-2-ethoxycarbonyl-4-phenylquinoline

Base Information

• Chemical Name: (+/-)-3-<3-(sec-butylamino)prop-1-yl>-2-ethoxycarbonyl-4-phenylquinoline
• CAS No.: 157139-92-9
• Molecular Formula: C₂₅H₃₀N₂O₂
• Molecular Weight: 390.525
• Mol file: 157139-92-9.mol

Synonyms:(+/-)-3-<3-(sec-butylamino)prop-1-yl>-2-ethoxycarbonyl-4-phenylquinoline

Chemical Property of (+/-)-3-<3-(sec-butylamino)prop-1-yl>-2-ethoxycarbonyl-4-phenylquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-3-<3-(sec-butylamino)prop-1-yl>-2-ethoxycarbonyl-4-phenylquinoline

There total 5 articles about (+/-)-3-<3-(sec-butylamino)prop-1-yl>-2-ethoxycarbonyl-4-phenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

(+/-)-E-3-<3-(sec-butylamino)-1-propen-1-yl>-2-ethoxycarbonyl-4-phenylquinoline (756792-11-7) → (+/-)-3-<3-(sec-butylamino)prop-1-yl>-2-ethoxycarbonyl-4-phenylquinoline (157139-92-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 0.666667h; under 1034.3 Torr;

DOI:10.3987/COM-93-6662

Reference yield:

3-bromomethyl-2-ethoxycarbonyl-4-phenylquinoline (154419-41-7) → (+/-)-3-<3-(sec-butylamino)prop-1-yl>-2-ethoxycarbonyl-4-phenylquinoline (157139-92-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 86 percent / benzene / 6 h / Heating

2: t-BuOK / benzene / 0.5 h / Ambient temperature

3: 2.) NBS, dibenzoyl peroxide / 1.) C₆H₆, reflux, 6 h, 2.) CCl₄, reflux, 2 h

4: ethanol / 0.5 h / Heating

5: 71 percent / H₂ / 10percent Pd/C / ethanol / 0.67 h / 1034.3 Torr

With N-Bromosuccinimide; potassium tert-butylate; hydrogen; dibenzoyl peroxide; palladium on activated charcoal; In ethanol; benzene;

DOI:10.3987/COM-93-6662

Reference yield:

E-3-(3-bromo-1-propen-1-yl)-2-ethoxycarbonyl-4-phenylquinoline (157139-90-7) → (+/-)-3-<3-(sec-butylamino)prop-1-yl>-2-ethoxycarbonyl-4-phenylquinoline (157139-92-9)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 0.5 h / Heating

2: 71 percent / H₂ / 10percent Pd/C / ethanol / 0.67 h / 1034.3 Torr

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.3987/COM-93-6662

upstream raw materials:

(+/-)-E-3-<3-(sec-butylamino)-1-propen-1-yl>-2-ethoxycarbonyl-4-phenylquinoline

3-bromomethyl-2-ethoxycarbonyl-4-phenylquinoline

E-3-(3-bromo-1-propen-1-yl)-2-ethoxycarbonyl-4-phenylquinoline