d8-N-[3-(3-fluoro-4-morpholin-4-yl-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide

Base Information

Chemical Name:d8-N-[3-(3-fluoro-4-morpholin-4-yl-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide
CAS No.:1032182-14-1
Molecular Formula:C₁₆H₂₀FN₃O₄
Molecular Weight:345.287
Hs Code.:

Synonyms:d8-N-[3-(3-fluoro-4-morpholin-4-yl-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide

Suppliers and Price of d8-N-[3-(3-fluoro-4-morpholin-4-yl-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 5 raw suppliers

Chemical Property of d8-N-[3-(3-fluoro-4-morpholin-4-yl-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide

Chemical Property:

Purity/Quality:: 95% by HPLC; 98% atom D ^*data from raw suppliers

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Technology Process of d8-N-[3-(3-fluoro-4-morpholin-4-yl-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide

There total 8 articles about d8-N-[3-(3-fluoro-4-morpholin-4-yl-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1138458-04-4
C₁₄H₁₀⁽²⁾H₈FN₃O₃

: 108-24-7
acetic anhydride

: 1032182-14-1
d8-N-[3-(3-fluoro-4-morpholin-4-yl-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide

Guidance literature:: In toluene; at 20 - 35 ℃; for 1.333h;

Reference yield: 50.0%

: 1032183-29-1
d8-(3-fluoro-4-morpholin-4-yl-phenyl)-carbamic acid benzyl ester

: 183905-31-9
N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

: 1032182-14-1
d8-N-[3-(3-fluoro-4-morpholin-4-yl-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide

Guidance literature:: d8-(3-fluoro-4-morpholin-4-yl-phenyl)-carbamic acid benzyl ester; With lithium tert-butoxide; In tetrahydrofuran; at 0 - 5 ℃; for 0.0833333h;

With methanol; In tetrahydrofuran; at 0 - 5 ℃; for 0.0833333h;

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 1032182-14-1
d8-N-[3-(3-fluoro-4-morpholin-4-yl-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: N-ethyl-N,N-diisopropylamine / ethyl acetate / 48.17 h / 0 - 20 °C

2: hydrogen / palladium 10% on activated carbon / ethanol

3: isopropyl alcohol / Heating / reflux

4: N,N-dimethyl-formamide / 5 h / 100 °C

5: dichloromethane / 20 °C

6: hydrazine / methanol / 1 h / Heating / reflux

7: toluene / 1.33 h / 20 - 35 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; hydrazine; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; toluene;