(6R,7R,8R)-9-acetyl-2,3-dimethyl-6-hydroxy-8-phenyl-7-pivaloyloxy-6,7,8,9-tetrahydro-3H-imidazo[4,5-h]quinoline

Base Information

Chemical Name:(6R,7R,8R)-9-acetyl-2,3-dimethyl-6-hydroxy-8-phenyl-7-pivaloyloxy-6,7,8,9-tetrahydro-3H-imidazo[4,5-h]quinoline
CAS No.:856706-62-2
Molecular Formula:C₂₅H₂₉N₃O₄
Molecular Weight:435.523
Hs Code.:

Synonyms:(6R,7R,8R)-9-acetyl-2,3-dimethyl-6-hydroxy-8-phenyl-7-pivaloyloxy-6,7,8,9-tetrahydro-3H-imidazo[4,5-h]quinoline

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Chemical Property of (6R,7R,8R)-9-acetyl-2,3-dimethyl-6-hydroxy-8-phenyl-7-pivaloyloxy-6,7,8,9-tetrahydro-3H-imidazo[4,5-h]quinoline

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Technology Process of (6R,7R,8R)-9-acetyl-2,3-dimethyl-6-hydroxy-8-phenyl-7-pivaloyloxy-6,7,8,9-tetrahydro-3H-imidazo[4,5-h]quinoline

There total 1 articles about (6R,7R,8R)-9-acetyl-2,3-dimethyl-6-hydroxy-8-phenyl-7-pivaloyloxy-6,7,8,9-tetrahydro-3H-imidazo[4,5-h]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 856706-61-1
(7R,8R)-9-acetyl-2,3-dimethyl-8-phenyl-7-pivaloyloxy-8,9-dihydro-3H,7H-imidazo[4,5-h]quinolin-6-one

: 856706-62-2
(6R,7R,8R)-9-acetyl-2,3-dimethyl-6-hydroxy-8-phenyl-7-pivaloyloxy-6,7,8,9-tetrahydro-3H-imidazo[4,5-h]quinoline

Guidance literature:: (7R,8R)-9-acetyl-2,3-dimethyl-8-phenyl-7-pivaloyloxy-8,9-dihydro-3H,7H-imidazo[4,5-h]quinolin-6-one; With sodium tetrahydroborate; In methanol; at -50 ℃; for 1h;

With hydrogenchloride; In methanol; water; at 0 ℃; pH=3;

With sodium hydrogencarbonate; In methanol; water;

Reference yield: 74.0%

: 856706-62-2
(6R,7R,8R)-9-acetyl-2,3-dimethyl-6-hydroxy-8-phenyl-7-pivaloyloxy-6,7,8,9-tetrahydro-3H-imidazo[4,5-h]quinoline

: (6R,7R,8R)-9-acetyl-2,3-dimethyl-6,7-dihydroxy-8-phenyl-6,7,8,9-tetrahydro-3H-imidazo[4,5-h]quinoline

Guidance literature:: With potassium carbonate; In methanol; for 3h;

Reference yield: 43.0%

: 856706-62-2
(6R,7R,8R)-9-acetyl-2,3-dimethyl-6-hydroxy-8-phenyl-7-pivaloyloxy-6,7,8,9-tetrahydro-3H-imidazo[4,5-h]quinoline

: 95353-04-1
trifluoromethanesulfonic acid 2-fluoroethyl ester

: (5R,6R,10R)-16,17-dimethyl-6-phenyl-2,3,6,7,10,17-hexahydro-5H-1,4-dioxa-7,15,17-triaza-cyclopenta[a]phenanthrene

: 856706-66-6
(5R,6R,10R)-7-acetyl-16,17-dimethyl-6-phenyl-2,3,6,7,10,17-hexahydro-5H-1,4-dioxa-7,15,17-triaza-cyclopenta[a]phenanthrene

Guidance literature:: (6R,7R,8R)-9-acetyl-2,3-dimethyl-6-hydroxy-8-phenyl-7-pivaloyloxy-6,7,8,9-tetrahydro-3H-imidazo[4,5-h]quinoline; trifluoromethanesulfonic acid 2-fluoroethyl ester; With sodium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; at -40 ℃; for 1h;

With water; ammonium chloride; In tetrahydrofuran; dichloromethane;

With potassium carbonate; ethanolamine; at 80 ℃; for 28h;