Rocephin

Base Information

• Chemical Name: Rocephin
• CAS No.: 104376-79-6
• Molecular Formula: 2(C18H16N8Na2O7S3)^.7(H2O)
• Molecular Weight: 1323.19
• Hs Code.: 29349990
• European Community (EC) Number: 277-930-0,277-405-6,626-956-4
• UNII: R598PB148Q
• DSSTox Substance ID: DTXSID501019136
• Wikipedia: Ceftriaxone
• NCI Thesaurus Code: C62020,C817
• RXCUI: 2193,203172
• Mol file: 104376-79-6.mol

Synonyms:Anhydrous Ceftriaxone Sodium;Benaxona;Cefatriaxone;Cefaxona;Ceftrex;Ceftriaxon;Ceftriaxon Curamed;Ceftriaxon Hexal;Ceftriaxona Andreu;Ceftriaxona LDP Torlan;Ceftriaxone;Ceftriaxone Irex;Ceftriaxone Sodium;Ceftriaxone Sodium, Anhydrous;Ceftriaxone, Disodium Salt;Ceftriaxone, Disodium Salt, Hemiheptahydrate;Lendacin;Longacef;Longaceph;Ro 13 9904;Ro 13-9904;Ro 139904;Ro-13-9904;Ro13 9904;Ro13-9904;Ro139904;Rocefalin;Rocefin;Rocephin;Rocephine;Tacex;Terbac

Chemical Property of Rocephin

Chemical Property:

• Appearance/Colour: White or almost white crystalline powder, odorless
• Melting Point: 236 °C
• Refractive Index: -160 ° (C=1, H2O)
• PKA: ~3 (COOH), 3.2 (NH3+), 4.1 (enolic OH)
• PSA: 299.72000
• LogP: -1.18550
• Storage Temp.: 2-8°C
• Solubility.: H2O: soluble50mg/mL
• Water Solubility.: Freely soluble in water
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 14
• Rotatable Bond Count: 7
• Exact Mass: 598.00994696
• Heavy Atom Count: 38
• Complexity: 1120

Purity/Quality:

98% ^*data from raw suppliers

Ceftriaxone disodium salt hemi(heptahydrate) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-42/43
• Safety Statements: 26-36-45-37-24-22

MSDS Files:

SDS file from LookChem

Useful:

• Drug Classes: Antiinfective Agents
• Canonical SMILES: CN1C(=NC(=O)C(=N1)[O-])SCC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)[O-].[Na+].[Na+]
• Isomeric SMILES: CN1C(=NC(=O)C(=N1)[O-])SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\OC)/C4=CSC(=N4)N)SC2)C(=O)[O-].[Na+].[Na+]
• Recent ClinicalTrials: Treatment Responses of Early Syphilis to Ceftriaxone Plus Doxycycline
• Recent EU Clinical Trials: 3-day intravenous antibiotic treatment versus 3-day intravenous followed by 7-day oral antibiotic treatment for acute pyelonephritis in children 1 month to 3 years old: a non-inferiority open randomized multicentric clinical trial
• Recent NIPH Clinical Trials: Open-label randomized comparative study of ceftriaxone vs. ampicillin/sulbactam in adults with mild to moderate community-acquired pneumonia
• Description: Ceftriaxone is a third-generation, broad-spectrum cephalosporin antibiotic that disrupts the synthesis of the peptidoglycan layer of bacterial cell walls. It has been shown to increase excitatory amino acid transporter-2 pump expression in the central nervous system and to reduce glutamatergic toxicity in both in vitro and in vivo models.
• Uses: antipsychotic An antibacterial, a third-generation cephalosporin. A potentially useful antibacterial agent for proteomics research.