3-((2S)-1-((2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)-1,1-dimethylurea

Base Information

Chemical Name:3-((2S)-1-((2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)-1,1-dimethylurea
CAS No.:1431531-03-1
Molecular Formula:C₂₃H₂₆FN₃O₄
Molecular Weight:427.476
Hs Code.:

Synonyms:3-((2S)-1-((2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)-1,1-dimethylurea

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Chemical Property of 3-((2S)-1-((2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)-1,1-dimethylurea

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Technology Process of 3-((2S)-1-((2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)-1,1-dimethylurea

There total 4 articles about 3-((2S)-1-((2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)-1,1-dimethylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1431532-74-9
tert-butyl ((2S)-1-((2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)carbamate

: 79-44-7
N,N-Dimethylcarbamoyl chloride

: 1431531-03-1
3-((2S)-1-((2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)-1,1-dimethylurea

Guidance literature:: tert-butyl ((2S)-1-((2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)carbamate; With hydrogenchloride; In ethyl acetate; at 20 ℃; for 0.166667h;

N,N-Dimethylcarbamoyl chloride; With triethylamine; In tetrahydrofuran; at 60 ℃; for 2h;

Reference yield:

: 350-29-8
3-fluoro-4-hydroxybenzoic acid

: 1431531-03-1
3-((2S)-1-((2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)-1,1-dimethylurea

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / methanol / 24 h / Reflux

1.2: 1 h / 70 °C

1.3: 2 h / 50 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

2.2: 2.25 h / 20 - 80 °C

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran; toluene / 16 h / 20 °C

4.1: hydrogenchloride / ethyl acetate / 0.17 h / 20 °C

4.2: 2 h / 60 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; sulfuric acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1021144-38-6
4-(cyclopropylmethoxy)-3-fluorobenzoic acid

: 1431531-03-1
3-((2S)-1-((2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)-1,1-dimethylurea

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

1.2: 2.25 h / 20 - 80 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran; toluene / 16 h / 20 °C

3.1: hydrogenchloride / ethyl acetate / 0.17 h / 20 °C

3.2: 2 h / 60 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; toluene;