alpha,alpha-Difluoro-1-naphthaleneacetic acid

Base Information

• Chemical Name: alpha,alpha-Difluoro-1-naphthaleneacetic acid
• CAS No.: 73790-14-4
• Molecular Formula: C₁₂H₈F₂O₂
• Molecular Weight: 222.191
• Hs Code.: 2916399090
• European Community (EC) Number: 824-002-3

Synonyms:73790-14-4;alpha,alpha-difluoro-1-naphthaleneacetic acid;2,2-Difluoro-2-(naphthalen-1-yl)acetic acid;2,2-difluoro-2-naphthalen-1-ylacetic acid;alpha,alpha-Difluoro-1-naphthaleneaceticAcid;MFCD16756770;SCHEMBL8185296;C12H8F2O2;TXILYIHFGBMXDH-UHFFFAOYSA-N;YCA79014;AC6716;AKOS011682263;AS-66169;SY038908;2,2-Difluoro-2-(naphthalen-1-yl)aceticacid;CS-0223087;EN300-1138319;A920341

Chemical Property of alpha,alpha-Difluoro-1-naphthaleneacetic acid

Chemical Property:

• XLogP3: 3.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 222.04923582
• Heavy Atom Count: 16
• Complexity: 278

Purity/Quality:

97% ^*data from raw suppliers

alpha,alpha-Difluoro-1-naphthaleneacetic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=CC=C2C(C(=O)O)(F)F

Technology Process of alpha,alpha-Difluoro-1-naphthaleneacetic acid

There total 5 articles about alpha,alpha-Difluoro-1-naphthaleneacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

ethyl α,α-difluoro-α-[1-(naphthyl)]acetate (73790-00-8) → α,α-difluoro-1-naphthaleneacetic acid (73790-14-4)

Guidance literature:

With hydrogen iodide; In acetic acid; for 1h; Heating;

DOI:10.1021/jo01302a025

Reference yield:

1-Iodonaphthalene (90-14-2) → α,α-difluoro-1-naphthaleneacetic acid (73790-14-4)

Guidance literature:

Multi-step reaction with 2 steps

1: copper / dimethyl sulfoxide / 12 h / 60 °C / Inert atmosphere

2: potassium carbonate / methanol / 2 h / 20 °C / Inert atmosphere

With copper; potassium carbonate; In methanol; dimethyl sulfoxide;

DOI:10.1002/ejoc.201701248

Reference yield:

1,1,1,3,3-pentafluoro-3-(naphthalen-1-yl)propane-2,2-diol → α,α-difluoro-1-naphthaleneacetic acid (73790-14-4)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 20 ℃;

DOI:10.1021/acs.joc.9b01595

upstream raw materials:

ethyl α,α-difluoro-α-[1-(naphthyl)]acetate

1-Bromonaphthalene

ethyl 2-(1-naphthyl)-2-oxoacetate

1-Iodonaphthalene

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 73790-14-4 α,α-difluoro-1-naphthaleneacetic acid

Send

Send

Metric Ton KG G Pound L ML

Send

Send