(4R,5S,6S)-<<5-(Methoxymethoxy)-4,6-dimethyl-8-(phenylsulfonyl)-1-octyl>oxy>(1,1-dimethylethyl)diphenylsilane

Base Information

Chemical Name:(4R,5S,6S)-<<5-(Methoxymethoxy)-4,6-dimethyl-8-(phenylsulfonyl)-1-octyl>oxy>(1,1-dimethylethyl)diphenylsilane
CAS No.:152033-14-2
Molecular Formula:C₃₄H₄₈O₅SSi
Molecular Weight:596.904
Hs Code.:

Synonyms:(4R,5S,6S)-<<5-(Methoxymethoxy)-4,6-dimethyl-8-(phenylsulfonyl)-1-octyl>oxy>(1,1-dimethylethyl)diphenylsilane

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Chemical Property of (4R,5S,6S)-<<5-(Methoxymethoxy)-4,6-dimethyl-8-(phenylsulfonyl)-1-octyl>oxy>(1,1-dimethylethyl)diphenylsilane

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Technology Process of (4R,5S,6S)-<<5-(Methoxymethoxy)-4,6-dimethyl-8-(phenylsulfonyl)-1-octyl>oxy>(1,1-dimethylethyl)diphenylsilane

There total 10 articles about (4R,5S,6S)-<<5-(Methoxymethoxy)-4,6-dimethyl-8-(phenylsulfonyl)-1-octyl>oxy>(1,1-dimethylethyl)diphenylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 165961-51-3
(4R,5S,6S)-<<5-(Methoxymethoxy)-4,6-dimethyl-8-(phenylthio)-1-octyl>oxy>(1,1-dimethylethyl)diphenylsilane

: 152033-14-2
(4R,5S,6S)-<<5-(Methoxymethoxy)-4,6-dimethyl-8-(phenylsulfonyl)-1-octyl>oxy>(1,1-dimethylethyl)diphenylsilane

Guidance literature:: With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1016/S0040-4039(00)74091-3

Reference yield:

: Ethyl (4R)-5-(tetrahydropyran-2-yloxy)-4-methyl-2-pentenoate

: 152033-14-2
(4R,5S,6S)-<<5-(Methoxymethoxy)-4,6-dimethyl-8-(phenylsulfonyl)-1-octyl>oxy>(1,1-dimethylethyl)diphenylsilane

Guidance literature:: Multi-step reaction with 10 steps

1: H₂ / 10percent Pd/C / ethyl acetate / 6 h / 25 °C

2: LiAlH₄ / diethyl ether / 0.5 h / 25 °C

3: 99 percent / imidazole / dimethylformamide / 18 h / 25 °C

4: 80 percent / p-TsOH*H₂O / methanol / 0.83 h / 25 °C

5: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 30 min, 2.) 25 deg C, 30 min

6: BF₃*Et₂O / CH₂Cl₂ / 1.) -86 deg C, 15 min; -86 to -70 deg C, 45 min, 2.) 0 deg C, 1 h

7: 100 percent / i-Pr₂NEt / CH₂Cl₂ / 18 h / 25 °C

8: 1.) 9-BBN, 2.) 3 N aq. NaOH, 31percent aq. H₂O₂ / 1.) THF, 25 deg C, 17 h, 2.) 25 deg C, 7 h

9: 87 percent / pyridine, n-Bu₃P / 45 h / 25 °C

10: 100 percent / 80percent m-CPBA, NaHCO₃ / CH₂Cl₂ / 1.5 h / 25 °C

With pyridine; 1H-imidazole; sodium hydroxide; lithium aluminium tetrahydride; 9-borabicyclo[3.3.1]nonane dimer; oxalyl dichloride; tributylphosphine; boron trifluoride diethyl etherate; hydrogen; dihydrogen peroxide; sodium hydrogencarbonate; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo00121a026

Reference yield:

: 123595-52-8
(2R)-2-Methyl-5-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-1-pentanol

: 152033-14-2
(4R,5S,6S)-<<5-(Methoxymethoxy)-4,6-dimethyl-8-(phenylsulfonyl)-1-octyl>oxy>(1,1-dimethylethyl)diphenylsilane

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 30 min, 2.) 25 deg C, 30 min

2: BF₃*Et₂O / CH₂Cl₂ / 1.) -86 deg C, 15 min; -86 to -70 deg C, 45 min, 2.) 0 deg C, 1 h

3: 100 percent / i-Pr₂NEt / CH₂Cl₂ / 18 h / 25 °C

4: 1.) 9-BBN, 2.) 3 N aq. NaOH, 31percent aq. H₂O₂ / 1.) THF, 25 deg C, 17 h, 2.) 25 deg C, 7 h

5: 87 percent / pyridine, n-Bu₃P / 45 h / 25 °C

6: 100 percent / 80percent m-CPBA, NaHCO₃ / CH₂Cl₂ / 1.5 h / 25 °C

With pyridine; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; oxalyl dichloride; tributylphosphine; boron trifluoride diethyl etherate; dihydrogen peroxide; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1021/jo00121a026