[5-(2,6-dimethoxy-5-methylpyrimidin-4-yl)cyclohex-3-ene-1,1-diyl]bis(methylene) dibenzoate

Base Information

• Chemical Name: [5-(2,6-dimethoxy-5-methylpyrimidin-4-yl)cyclohex-3-ene-1,1-diyl]bis(methylene) dibenzoate
• CAS No.: 1269417-35-7
• Molecular Formula: C₂₉H₃₀N₂O₆
• Molecular Weight: 502.567
• Mol file: 1269417-35-7.mol

Synonyms:[5-(2,6-dimethoxy-5-methylpyrimidin-4-yl)cyclohex-3-ene-1,1-diyl]bis(methylene) dibenzoate

Chemical Property of [5-(2,6-dimethoxy-5-methylpyrimidin-4-yl)cyclohex-3-ene-1,1-diyl]bis(methylene) dibenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of [5-(2,6-dimethoxy-5-methylpyrimidin-4-yl)cyclohex-3-ene-1,1-diyl]bis(methylene) dibenzoate

There total 1 articles about [5-(2,6-dimethoxy-5-methylpyrimidin-4-yl)cyclohex-3-ene-1,1-diyl]bis(methylene) dibenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

4-iodo-2,6-dimethoxy-5-methylpyrimidine (1269417-32-4) + (5-chlorocyclohex-3-ene-1,1-diyl)bis(methylene) dibenzoate (1269417-33-5) → [5-(2,6-dimethoxy-5-methylpyrimidin-4-yl)cyclohex-3-ene-1,1-diyl]bis(methylene) dibenzoate (1269417-35-7)

Guidance literature:

4-iodo-2,6-dimethoxy-5-methylpyrimidine; With TurboGrignard; In tetrahydrofuran; at -25 ℃; for 1h; Inert atmosphere;

(5-chlorocyclohex-3-ene-1,1-diyl)bis(methylene) dibenzoate; With copper(l) iodide; lithium chloride; In tetrahydrofuran; at -25 ℃; for 48h; Inert atmosphere;

DOI:10.1055/s-0030-1258271

Reference yield: 93.0%

[5-(2,6-dimethoxy-5-methylpyrimidin-4-yl)cyclohex-3-ene-1,1-diyl]bis(methylene) dibenzoate (1269417-35-7) → [3-(2,6-dimethoxy-5-methylpyrimidin-4-yl)cyclohexane-1,1-diyl]bis(methylene) dibenzoate (1269417-41-5)

Guidance literature:

With 20 % Pd(OH)2/C; hydrogen; In methanol; for 20h;

DOI:10.1055/s-0030-1258271

upstream raw materials:

4-iodo-2,6-dimethoxy-5-methylpyrimidine

(5-chlorocyclohex-3-ene-1,1-diyl)bis(methylene) dibenzoate

Downstream raw materials:

[3-(2,6-dimethoxy-5-methylpyrimidin-4-yl)cyclohexane-1,1-diyl]bis(methylene) dibenzoate