1-cyclopropyl-4-{4-[(3-{3-[3-fluoro-4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-5-methyl-1H-pyrazol-1-yl)methyl]pyridin-2-yl}piperazine

Base Information

Chemical Name:1-cyclopropyl-4-{4-[(3-{3-[3-fluoro-4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-5-methyl-1H-pyrazol-1-yl)methyl]pyridin-2-yl}piperazine
CAS No.:1227159-16-1
Molecular Formula:C₂₆H₂₅F₄N₇O₂
Molecular Weight:543.524
Hs Code.:

Synonyms:1-cyclopropyl-4-{4-[(3-{3-[3-fluoro-4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-5-methyl-1H-pyrazol-1-yl)methyl]pyridin-2-yl}piperazine

Suppliers and Price of 1-cyclopropyl-4-{4-[(3-{3-[3-fluoro-4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-5-methyl-1H-pyrazol-1-yl)methyl]pyridin-2-yl}piperazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-cyclopropyl-4-{4-[(3-{3-[3-fluoro-4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-5-methyl-1H-pyrazol-1-yl)methyl]pyridin-2-yl}piperazine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-cyclopropyl-4-{4-[(3-{3-[3-fluoro-4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-5-methyl-1H-pyrazol-1-yl)methyl]pyridin-2-yl}piperazine

There total 4 articles about 1-cyclopropyl-4-{4-[(3-{3-[3-fluoro-4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-5-methyl-1H-pyrazol-1-yl)methyl]pyridin-2-yl}piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1227160-32-8
3-[3-fluoro-4-(trifluoromethoxy)phenyl]-5-(5-methyl-1H-pyrazol-3-yl)-1,2,4-oxadiazole

: 1227160-33-9
1-[4-(chloromethyl)pyridin-2-yl]-4-cyclopropylpiperazine

: 1227159-16-1
1-cyclopropyl-4-{4-[(3-{3-[3-fluoro-4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-5-methyl-1H-pyrazol-1-yl)methyl]pyridin-2-yl}piperazine

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; Reflux;

Reference yield:

: 100704-10-7
(2-chloropyridin-4-yl)methanol

: 1227159-16-1
1-cyclopropyl-4-{4-[(3-{3-[3-fluoro-4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-5-methyl-1H-pyrazol-1-yl)methyl]pyridin-2-yl}piperazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / 150 °C

2.1: acetic acid / methanol / 0.17 h / 20 °C / Molecular sieve

2.2: 2 h / Reflux

3.1: thionyl chloride / dichloromethane / 4.67 h / 20 °C

4.1: potassium tert-butylate / tetrahydrofuran / Reflux

With thionyl chloride; potassium tert-butylate; acetic acid; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1227160-34-0
[2-(piperazin-1-yl)pyridin-4-yl]methanol

: 1227159-16-1
1-cyclopropyl-4-{4-[(3-{3-[3-fluoro-4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-5-methyl-1H-pyrazol-1-yl)methyl]pyridin-2-yl}piperazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / methanol / 0.17 h / 20 °C / Molecular sieve

1.2: 2 h / Reflux

2.1: thionyl chloride / dichloromethane / 4.67 h / 20 °C

3.1: potassium tert-butylate / tetrahydrofuran / Reflux

With thionyl chloride; potassium tert-butylate; acetic acid; In tetrahydrofuran; methanol; dichloromethane;