2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(6-(trifluoromethoxy)quinoxalin-2-yl)propan-2-ol

Base Information

Chemical Name:2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(6-(trifluoromethoxy)quinoxalin-2-yl)propan-2-ol
CAS No.:1416805-79-2
Molecular Formula:C₁₉H₁₁F₇N₆O₂
Molecular Weight:488.324
Hs Code.:

Synonyms:2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(6-(trifluoromethoxy)quinoxalin-2-yl)propan-2-ol

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Chemical Property of 2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(6-(trifluoromethoxy)quinoxalin-2-yl)propan-2-ol

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Technology Process of 2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(6-(trifluoromethoxy)quinoxalin-2-yl)propan-2-ol

There total 7 articles about 2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(6-(trifluoromethoxy)quinoxalin-2-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.4%

: 1416806-28-4
C₁₈H₉F₇N₂O₂

: 13440-29-4
1H-tetrazole sodium salt

: 1416805-79-2
2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(6-(trifluoromethoxy)quinoxalin-2-yl)propan-2-ol

Guidance literature:: C₁₈H₉F₇N₂O₂; 1H-tetrazole sodium salt; In N,N-dimethyl-formamide; at 20 - 65 ℃; Inert atmosphere;

With water; In N,N-dimethyl-formamide; Cooling with ice;

Reference yield:

: 2267-22-3
2-nitro-5-(trifluoromethoxy)aniline

: 1416805-79-2
2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(6-(trifluoromethoxy)quinoxalin-2-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen / palladium-on-charcoal / ethanol / 16 h / 20 °C / Inert atmosphere

2.1: methanol / 0 - 20 °C

3.1: phosphorus(V) oxybromide / 20 - 130 °C

4.1: copper / dimethyl sulfoxide / 1 h / 20 °C

4.2: 16 h / 20 °C

5.1: n-butyllithium / hexane; diethyl ether / 0.5 h / -78 °C / Inert atmosphere

5.2: 1 h / -78 °C / Inert atmosphere

6.1: diethyl ether / 0 - 20 °C

7.1: N,N-dimethyl-formamide / 20 - 65 °C / Inert atmosphere

7.2: Cooling with ice

With n-butyllithium; hydrogen; copper; phosphorus(V) oxybromide; palladium-on-charcoal; In methanol; diethyl ether; ethanol; hexane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 658-89-9
4-(trifluoromethoxy)benzene-1,2-diamine

: 1416805-79-2
2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(6-(trifluoromethoxy)quinoxalin-2-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: methanol / 0 - 20 °C

2.1: phosphorus(V) oxybromide / 20 - 130 °C

3.1: copper / dimethyl sulfoxide / 1 h / 20 °C

3.2: 16 h / 20 °C

4.1: n-butyllithium / hexane; diethyl ether / 0.5 h / -78 °C / Inert atmosphere

4.2: 1 h / -78 °C / Inert atmosphere

5.1: diethyl ether / 0 - 20 °C

6.1: N,N-dimethyl-formamide / 20 - 65 °C / Inert atmosphere

6.2: Cooling with ice

With n-butyllithium; copper; phosphorus(V) oxybromide; In methanol; diethyl ether; hexane; dimethyl sulfoxide; N,N-dimethyl-formamide;