C₃₂H₄₇NO₅Si

Base Information

• Chemical Name: C₃₂H₄₇NO₅Si
• CAS No.: 1403235-20-0
• Molecular Formula: C₃₂H₄₇NO₅Si
• Molecular Weight: 553.814
• Mol file: 1403235-20-0.mol

Synonyms:C₃₂H₄₇NO₅Si

Chemical Property of C₃₂H₄₇NO₅Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₂H₄₇NO₅Si

There total 3 articles about C₃₂H₄₇NO₅Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

C26H33NO5 (1403235-19-7) + triethylsilyl trifluoromethyl sulfonate (79271-56-0) → C32H47NO5Si (1403235-20-0)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/ol302309c

Reference yield:

C14H20O (1403235-36-8) → C32H47NO5Si (1403235-20-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / tert-butyl alcohol; water; tetrahydrofuran / 12 h / Inert atmosphere

1.2: 3 h / 0 - 20 °C / Inert atmosphere

2.1: di-n-butylboryl trifluoromethanesulfonate / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

2.2: 1 h / 0 °C / Inert atmosphere

2.3: 6 h / -78 - 0 °C / Inert atmosphere

3.1: 2,6-dimethylpyridine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

With 2,6-dimethylpyridine; osmium(VIII) oxide; di-n-butylboryl trifluoromethanesulfonate; 4-methylmorpholine N-oxide; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol; 2.1: |Evans Aldol Reaction / 2.2: |Evans Aldol Reaction / 2.3: |Evans Aldol Reaction;

DOI:10.1021/ol302309c

Reference yield:

C16H22O2S2 (1403235-18-6) → C32H47NO5Si (1403235-20-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tri-n-butyl-tin hydride; 2,2'-azobis(isobutyronitrile) / toluene / 12 h / Reflux; Inert atmosphere

2.1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / tert-butyl alcohol; water; tetrahydrofuran / 12 h / Inert atmosphere

2.2: 3 h / 0 - 20 °C / Inert atmosphere

3.1: di-n-butylboryl trifluoromethanesulfonate / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

3.2: 1 h / 0 °C / Inert atmosphere

3.3: 6 h / -78 - 0 °C / Inert atmosphere

4.1: 2,6-dimethylpyridine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

With 2,6-dimethylpyridine; osmium(VIII) oxide; 2,2'-azobis(isobutyronitrile); di-n-butylboryl trifluoromethanesulfonate; tri-n-butyl-tin hydride; 4-methylmorpholine N-oxide; In tetrahydrofuran; dichloromethane; water; toluene; tert-butyl alcohol; 1.1: |Barton-McCombie Deoxygenation / 3.1: |Evans Aldol Reaction / 3.2: |Evans Aldol Reaction / 3.3: |Evans Aldol Reaction;

DOI:10.1021/ol302309c

upstream raw materials:

C₁₄H₂₀O

C₂₆H₃₃NO₅

triethylsilyl trifluoromethyl sulfonate

C₁₆H₂₂O₂S₂

Downstream raw materials:

C₂₂H₄₀O₃Si

C₂₉H₄₆O₅SSi

C₄₁H₆₉NO₈Si

C₃₅H₅₅NO₈