N-[(4-chlorophenyl)-methyl]-2-(ethylsulfonyl)-6-methyl-4-morpholin-4-yl-benzamide

Base Information

Chemical Name:N-[(4-chlorophenyl)-methyl]-2-(ethylsulfonyl)-6-methyl-4-morpholin-4-yl-benzamide
CAS No.:1472103-80-2
Molecular Formula:C₂₁H₂₅ClN₂O₄S
Molecular Weight:436.96
Hs Code.:

Synonyms:N-[(4-chlorophenyl)-methyl]-2-(ethylsulfonyl)-6-methyl-4-morpholin-4-yl-benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(4-chlorophenyl)-methyl]-2-(ethylsulfonyl)-6-methyl-4-morpholin-4-yl-benzamide

Chemical Property:

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Technology Process of N-[(4-chlorophenyl)-methyl]-2-(ethylsulfonyl)-6-methyl-4-morpholin-4-yl-benzamide

There total 5 articles about N-[(4-chlorophenyl)-methyl]-2-(ethylsulfonyl)-6-methyl-4-morpholin-4-yl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1472104-24-7
2-(ethylsulfonyl)-6-methyl-4-morpholin-4-yl-benzamide

: 622-95-7
4-chlorobenzyl bromide

: 1472103-80-2
N-[(4-chlorophenyl)-methyl]-2-(ethylsulfonyl)-6-methyl-4-morpholin-4-yl-benzamide

Guidance literature:: With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide; In tetrahydrofuran; benzene; at 23 - 70 ℃; for 0.416667h;

Reference yield:

: 1472104-14-5
4-chloro-2-ethylsulfanyl-6-methyl-benzonitrile

: 1472103-80-2
N-[(4-chlorophenyl)-methyl]-2-(ethylsulfonyl)-6-methyl-4-morpholin-4-yl-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: m-chloroperoxybenzoic acid / dichloromethane / 1.5 h / 0 - 23 °C

2: potassium carbonate / 1-methyl-pyrrolidin-2-one / 48 h / 150 °C / Sealed tube

3: sulfuric acid / 1.5 h / 100 °C

4: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / benzene; tetrahydrofuran / 0.42 h / 23 - 70 °C

With m-chloroperoxybenzoic acid; sulfuric acid; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; sodium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; benzene;

Reference yield:

: 175277-98-2
2,4-dichloro-6-methyl-benzonitrile

: 1472103-80-2
N-[(4-chlorophenyl)-methyl]-2-(ethylsulfonyl)-6-methyl-4-morpholin-4-yl-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium phosphate; L-proline / N,N-dimethyl-formamide / 0.5 h / 23 °C / Sealed tube; Inert atmosphere

1.2: 16 h / 23 - 80 °C

2.1: m-chloroperoxybenzoic acid / dichloromethane / 1.5 h / 0 - 23 °C

3.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 48 h / 150 °C / Sealed tube

4.1: sulfuric acid / 1.5 h / 100 °C

5.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / benzene; tetrahydrofuran / 0.42 h / 23 - 70 °C

With potassium phosphate; m-chloroperoxybenzoic acid; sulfuric acid; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; L-proline; sodium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide; benzene;