ethyl 3,4-bis(acetyloxy)-6-(3-chloro-4-fluorobenzyl)-5-oxo-5,6,7,8-tetrahydro-2,6-naphthyridine-1-carboxylate

Base Information

Chemical Name:ethyl 3,4-bis(acetyloxy)-6-(3-chloro-4-fluorobenzyl)-5-oxo-5,6,7,8-tetrahydro-2,6-naphthyridine-1-carboxylate
CAS No.:865300-52-3
Molecular Formula:C₂₂H₂₀ClFN₂O₇
Molecular Weight:478.861
Hs Code.:

Synonyms:ethyl 3,4-bis(acetyloxy)-6-(3-chloro-4-fluorobenzyl)-5-oxo-5,6,7,8-tetrahydro-2,6-naphthyridine-1-carboxylate

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Chemical Property of ethyl 3,4-bis(acetyloxy)-6-(3-chloro-4-fluorobenzyl)-5-oxo-5,6,7,8-tetrahydro-2,6-naphthyridine-1-carboxylate

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Technology Process of ethyl 3,4-bis(acetyloxy)-6-(3-chloro-4-fluorobenzyl)-5-oxo-5,6,7,8-tetrahydro-2,6-naphthyridine-1-carboxylate

There total 6 articles about ethyl 3,4-bis(acetyloxy)-6-(3-chloro-4-fluorobenzyl)-5-oxo-5,6,7,8-tetrahydro-2,6-naphthyridine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 865088-75-1
1-(3-chloro-4-fluorobenzyl)-5,6-dihydropyridin-2(1H)-one

: 865300-52-3
ethyl 3,4-bis(acetyloxy)-6-(3-chloro-4-fluorobenzyl)-5-oxo-5,6,7,8-tetrahydro-2,6-naphthyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: water / 72 h / 0 - 135 °C

2.1: dihydrogen peroxide; acetic acid / water / 4 h / 100 °C

2.2: 0 - 40 °C

3.1: 1 h / 100 °C

With water; dihydrogen peroxide; acetic acid; In water;

Reference yield:

: 865300-49-8
1-(3-chloro-4-fluorobenzyl)piperidin-2-one

: 865300-52-3
ethyl 3,4-bis(acetyloxy)-6-(3-chloro-4-fluorobenzyl)-5-oxo-5,6,7,8-tetrahydro-2,6-naphthyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 3.33 h / -20 °C

2.1: water / 72 h / 0 - 135 °C

3.1: dihydrogen peroxide; acetic acid / water / 4 h / 100 °C

3.2: 0 - 40 °C

4.1: 1 h / 100 °C

With water; dihydrogen peroxide; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; water;

Reference yield:

: 865300-22-7
butyl N-[ethoxy(oxo)acetyl]glycinate

: 865300-52-3
ethyl 3,4-bis(acetyloxy)-6-(3-chloro-4-fluorobenzyl)-5-oxo-5,6,7,8-tetrahydro-2,6-naphthyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: phosphorus pentoxide / water; acetonitrile / 1 h / 20 - 60 °C

2.1: water / 72 h / 0 - 135 °C

3.1: dihydrogen peroxide; acetic acid / water / 4 h / 100 °C

3.2: 0 - 40 °C

4.1: 1 h / 100 °C

With water; dihydrogen peroxide; phosphorus pentoxide; acetic acid; In water; acetonitrile;