N-(4-(4-(hydroxymethyl)pyridin-3-yl)-3-methoxyphenyl)methanesulfonamide

Base Information

Chemical Name:N-(4-(4-(hydroxymethyl)pyridin-3-yl)-3-methoxyphenyl)methanesulfonamide
CAS No.:1357094-45-1
Molecular Formula:C₁₄H₁₆N₂O₄S
Molecular Weight:308.358
Hs Code.:

Synonyms:N-(4-(4-(hydroxymethyl)pyridin-3-yl)-3-methoxyphenyl)methanesulfonamide

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Chemical Property of N-(4-(4-(hydroxymethyl)pyridin-3-yl)-3-methoxyphenyl)methanesulfonamide

Chemical Property:

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Technology Process of N-(4-(4-(hydroxymethyl)pyridin-3-yl)-3-methoxyphenyl)methanesulfonamide

There total 3 articles about N-(4-(4-(hydroxymethyl)pyridin-3-yl)-3-methoxyphenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1357095-13-6
N-(4-(4-formylpyridin-3-yl)-3-methoxyphenyl)methanesulfonamide

: 1357094-45-1
N-(4-(4-(hydroxymethyl)pyridin-3-yl)-3-methoxyphenyl)methanesulfonamide

Guidance literature:: N-(4-(4-formylpyridin-3-yl)-3-methoxyphenyl)methanesulfonamide; With methanol; sodium tetrahydroborate; In tetrahydrofuran; at 20 ℃; for 0.333333h;

With hydrogenchloride; In tetrahydrofuran; water; pH=1;

Reference yield:

: 177360-09-7
N-(4-bromo-3-methoxyphenyl)methanesulfonamide

: 1357094-45-1
N-(4-(4-(hydroxymethyl)pyridin-3-yl)-3-methoxyphenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tert.-butyl lithium; methyllithium / hexane; pentane; tetrahydrofuran / 0.5 h / -78 °C

1.2: 16 h / 20 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol; water / 16 h / 90 °C / Inert atmosphere; sealed tube

3.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 0.33 h / 20 °C

3.2: pH 1

With methanol; sodium tetrahydroborate; methyllithium; tert.-butyl lithium; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; hexane; water; pentane;

Reference yield:

: 1357095-04-5
N-(3-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanesulfonamide

: 1357094-45-1
N-(4-(4-(hydroxymethyl)pyridin-3-yl)-3-methoxyphenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol; water / 16 h / 90 °C / Inert atmosphere; sealed tube

2.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 0.33 h / 20 °C

2.2: pH 1

With methanol; sodium tetrahydroborate; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water;