1H-Isoindol-1-one,5-amino-2,3-dihydro-(9CI)

Base Information

• Chemical Name: 1H-Isoindol-1-one,5-amino-2,3-dihydro-(9CI)
• CAS No.: 222036-66-0
• Molecular Formula: C8H8N2O
• Molecular Weight: 148.164
• Hs Code.: 2933790090
• Mol file: 222036-66-0.mol

Synonyms:5-Amino-2,3-dihydro-1H-isoindol-1-one;5-Amino-2,3-dihydroisoindol-1-one;1H-isoindol-1-one, 5-amino-2,3-dihydro;

Chemical Property of 1H-Isoindol-1-one,5-amino-2,3-dihydro-(9CI)

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 197-199 °C(Solv: ethyl acetate (141-78-6))
• Refractive Index: 1.654
• Boiling Point: 520.034 °C at 760 mmHg
• PKA: 15.12±0.20(Predicted)
• Flash Point: 268.307 °C
• PSA: 55.12000
• Density: 1.307g/cm³
• LogP: 1.42220
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

5-Aminoisoindolin-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Aminoisoindolin-1-one is used in the synthesis of a novel potent glycoprotein IIb-IIIa (GP IIb-IIIa) receptor antagonist based on the isoindolone skeleton.

Technology Process of 1H-Isoindol-1-one,5-amino-2,3-dihydro-(9CI)

There total 10 articles about 1H-Isoindol-1-one,5-amino-2,3-dihydro-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

C10H7F3N2O2 (1357104-53-0) → 5-amino-2,3-dihydro-1H-benzo[c]azol-1-one (222036-66-0)

Guidance literature:

With potassium carbonate; In methanol;

DOI:10.1016/j.bmcl.2011.12.063

Reference yield: 84.0%

2,3-Dihydro-6-nitro-1H-isoindol-1-on (110568-64-4,876343-38-3) → 5-amino-2,3-dihydro-1H-benzo[c]azol-1-one (222036-66-0)

Guidance literature:

With hydrogenchloride; iron; In ethanol; water; for 2h; Heating;

Reference yield: 64.0%

ethyl 4-amino-2-aminomethyl-benzoate monohydrochloride (1113057-04-7) → 5-amino-2,3-dihydro-1H-benzo[c]azol-1-one (222036-66-0)

Guidance literature:

With dmap; triethylamine; In N,N-dimethyl-formamide; at 110 ℃; for 2h;

upstream raw materials:

3-aminophthalimide

2,3-Dihydro-6-nitro-1H-isoindol-1-on

ethyl 4-amino-2-aminomethyl-benzoate monohydrochloride

2-methyl-4-nitrobenzoic acid

Downstream raw materials:

1-(7-(3,4-dimethoxyphenylamino)thiazolo[5,4-d]pyrimidin-5-yl)-N-(1-oxoisoindolin-5-yl)piperidine-3-carboxamide

1-(4-((2-((1-oxoisoindolin-5-yl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(1-(p-tolyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)urea

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