2-(7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)aceticacid

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Chemical Name:2-(7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)aceticacid
CAS No.:1215118-42-5
Molecular Formula:C₂₄H₂₄F₃NO₄
Molecular Weight:447.454
Hs Code.:

Synonyms:2-(7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)aceticacid

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Chemical Property of 2-(7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)aceticacid

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Technology Process of 2-(7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)aceticacid

There total 18 articles about 2-(7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)aceticacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1215118-95-8
tert-butyl 2-(7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

: 1215118-42-5
2-(7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)aceticacid

Guidance literature:: With water; lithium hydroxide; In 1,4-dioxane; at 70 ℃; for 4h;
DOI:10.1021/ml500422m

Reference yield:

: 16732-70-0
ethyl 5-bromoindolecarboxylate

: 1215118-42-5
2-(7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)aceticacid

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / toluene; mineral oil / 110 °C

1.2: 48 h / 110 °C

1.3: 16 h / Reflux

2.1: tetrahydrofuran / 16 h / 65 °C

3.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 1.5 h / 90 °C / Inert atmosphere

4.1: sodium hydroxide; dihydrogen peroxide / water; tetrahydrofuran / 0.42 h / 23 °C

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; water / 3 h / 4913.04 Torr

6.1: caesium carbonate / ISOPROPYLAMIDE / 16 h / 80 °C

7.1: water; lithium hydroxide / dioxanes / 4 h / 70 °C

7.2: pH 3

With water; hydrogen; dihydrogen peroxide; potassium acetate; sodium hydride; caesium carbonate; sodium hydroxide; lithium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; dioxanes; ISOPROPYLAMIDE; water; ethyl acetate; toluene; mineral oil;

Reference yield:

: 1174512-53-8
7-bromo-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-one

: 1215118-42-5
2-(7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)aceticacid

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 16 h / 65 °C

2.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 1.5 h / 90 °C / Inert atmosphere

3.1: sodium hydroxide; dihydrogen peroxide / water; tetrahydrofuran / 0.42 h / 23 °C

4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; water / 3 h / 4913.04 Torr

5.1: caesium carbonate / ISOPROPYLAMIDE / 16 h / 80 °C

6.1: water; lithium hydroxide / dioxanes / 4 h / 70 °C

6.2: pH 3

With water; hydrogen; dihydrogen peroxide; potassium acetate; caesium carbonate; sodium hydroxide; lithium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; dioxanes; ISOPROPYLAMIDE; water; ethyl acetate;