Synonyms:5-bromo-5-trifluoromethyl-5,6-dihydrouracil
There total 1 articles about 5-bromo-5-trifluoromethyl-5,6-dihydrouracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
Reference yield: 9.0%
The research focuses on the development of a new synthetic route to S-substituted uridines, which are important modified nucleosides found in transfer RNA. The purpose of the study was to devise a method for the transformation of uridine into these substituted derivatives, leveraging the use of lithiation, a technique that has gained recognition in nucleoside chemistry for carbon-carbon bond forming reactions. The researchers found that 2’,3’-O-isopropylidene-5’-O-methoxymethyl-5,6-dihydrouridine could serve as an "amide α-anion" upon lithiation with lithium diisopropylamide (LDA). Through a series of reactions involving anion formation, acylation, phenylselenation, and oxidative elimination, they successfully synthesized S-acyluridines and S-alkyluridines. Key chemicals used in the process included butyllithium, acid chlorides, phenylselenyl chloride, and various alkylating agents. The conclusions of the research provide a new entry to S-substituted uridines and demonstrate the effectiveness of the developed synthetic routes, offering a practical and efficient method for the preparation of these compounds.
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