Chemical Property of Ginsenoside Rd
Chemical Property:
- Vapor Pressure:0mmHg at 25°C
- Melting Point:204～206℃
- Refractive Index:1.61
- Boiling Point:1020.4 °C at 760 mmHg
- PKA:12.85±0.70(Predicted)
- Flash Point:570.9 °C
- PSA：298.14000
- Density:1.37 g/cm3
- LogP:-0.02680
- Storage Temp.:2-8°C
- Solubility.:DMSO (Slightly), Methanol (Slightly)
- XLogP3:2.4
- Hydrogen Bond Donor Count:12
- Hydrogen Bond Acceptor Count:18
- Rotatable Bond Count:13
- Exact Mass:946.55011576
- Heavy Atom Count:66
- Complexity:1680
- Purity/Quality:
-
99%, *data from raw suppliers
Ginsenoside Rd *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn
- Statements:
22
- Safety Statements:
2-45
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CCC4C3(CCC(C4(C)C)OC5C(C(C(C(O5)CO)O)O)OC6C(C(C(C(O6)CO)O)O)O)C)C)O)C)OC7C(C(C(C(O7)CO)O)O)O)C
- Isomeric SMILES:CC(=CCC[C@@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C)C)O)C)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O)C
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Description
Ginsenosides are pharmacologically active natural constituents of ginseng and other plants of the genus Panax. Structurally, they are steroid glycosides derived from the triterpene squalene. Ginsenoside Rd is a protopanaxadiol which is more abundant in some Panax species (e.g., P. quinquefolium) than others. This ginsenoside has diverse in vitro and in vivo effects, including cardioprotective, neuroprotective, and anti-inflammatory actions. Notably, ginsenoside Rd is converted to other ginsenosides in response to steaming or heating plant materials, leading to loss of these activities.
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Uses
Ginsenoside RD has been shown to attenuate tau protein phosphorylation via the PI3K/AKT/GSK-3β pathway after forebrain ischemia. This could be used to counter the risk of developing post-stroke dementia.
